肝癌患者血清中AFP CEA VEGF和AFU的表达及临床意义

目的:检测甲胎蛋白(AFP)、癌胚抗原(CEA)、血管内皮生长因子(VEGF)和a-L-岩藻糖苷酶(AFU)在肝癌患者血清中的表达,探讨其联合检测的意义,以期为研究肝癌发生、发展提供理论支持.方法:以145例肝癌患者的血清标本作为研究对象,同时选取76例健康体检患者作为对照组,检测血清中AFP、CEA、VEGF和AFU的表达,分析其在不同临床特征之间的关系.结果:AFP、CEA、VEGF和AFU在肝癌患者血清中高表达,且AFP、CEA、VEGF和AFU的表达与肝癌患者的肿瘤体积及临床分期密切相关.肝癌中VEGF与AFU的表达具有正相关性.结论:AFP、CEA、VEGF和AFU肝癌患者血清中表达增高,在肝癌发生发展中具有重要作用.早期联合检测四者对诊断及判断肝癌的预后可能有一定价值.

Expressions and clinical significance of AFP,CEA,VEGF and AFU in patients with hepatocarcinoma

Objective：To detect the expressions of serum AFP,CEA,VEGF and AFU in the patients with liver carcinoma and to investigate the clinical significance of combination detection to provide theoretic basis for studying the occurrence and development of liver cancer.Methods：The serum samples of 145 patients with hepatocarcinoma were collected as observation group,and 76 normal adults were observed as control group.The expressions of serum AFP,CEA,VEGF and AFU were detected in the two groups.The relation between the clinical characteristics was analyzed in the observation group.Results：The expressions of serum AFP,CEA,VEGF and AFU were obviously higher in the observation group than in the control group.The expressions of AFP,CEA,VEGF and AFU were obviously correlated with diameter of tumor and clinical stage in the observation group.There was positive correlation between VEGF and AFU in the observation group.Conclusion：The increased expressions of AFP,CEA,VEGF and AFU can induce the occrrence of liver carcinoma.The combined examination of AFP,CEA,VEGF and AFU are helpful to predict the prognosis in liver carcinoma.