Acetylcarbocholine and acetylsilicocholine: Directly or indirectly acting cholinergic spasmogens? |
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Authors: | P. TH. HENDERSON,E. J. ARIË NS,B. W. J. ELLENBROEK,A. M. SIMONIS |
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Abstract: | The cholinergic and anticholinergic actions of nitrogen-free isosteres of acetylcholine and benzilylcholine are described. Esters of two kinds of choline analogues, carbocholine and silicocholine, were used. The spasmogenic activity of acetylcarbocholine and acetylsilicocholine on the guinea-pig ileum was identified as an indirect cholinergic action, in contrast to the direct cholinergic action of furtrethonium and the mainly non-cholinergic action of barium ions. In addition to this indirect cholinergic action, both esters show a weak anticholinergic and a weak noncompetitive “papaverine-like” spasmolytic activity. The corresponding benzilyl esters, although without an onium group, are relatively potent anticholinergic compounds. |
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