|
|||||
|
|
Role of plasma glucose level on myocardial perfusion in ST-segment elevation myocardial infarction patients |
|
| Authors: | Martino Pepe Domenico Zanna Alessandro Cafaro Alfredo Marchese Francesco Addabbo Eliano Pio Navarese Massimo Napodano Annagrazia Cecere Fabrizio Resta Valeria Paradies Alessandro Santo Bortone Stefano Favale |
| Affiliation: | 1. Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy;2. Department of Cardiology, General Hospital “F. Miulli”, Acquaviva delle Fonti, Bari, Italy;3. Department of Cardiology, Anthea Hospital, GVM Care & Research, Bari, Italy;4. Department of Biomedical Sciences & Human Oncology, University of Bari Medical School, Bari, Italy;5. Department of Internal Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine-University, Düsseldorf, Germany;6. Department of Cardiac, Thoracic and Vascular Sciences, Hospital-University of Padova, Padova, Italy;g. Department of Cardiology, “Santa Maria” Hospital, GVM Care & Research, Bari, Italy;h. Department of Cardiology, Maasstad Ziekenhuis Hospital, Rotterdam, Netherlands;i. Division of Heart Surgery, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy |
| Abstract: | AimsHyperglycemia is frequent in patients with ST elevation myocardial infarction (STEMI) and is associated with adverse outcome. Aim of our study was to evaluate the correlation between admission plasma glucose level (PGL) and coronary arteries flow velocity.MethodsWe enrolled 149 STEMI patients successfully treated with primary percutaneous coronary intervention (pPCI). The study population was divided into two groups based on PGL (< or >140?mg/dl) and on history of diabetes, and the groups compared in terms of corrected TIMI frame count (cTFC).ResultsHyperglycemic patients had a significantly higher cTFC in both the culprit (p?ConclusionsAdmission PGL affects coronary flow of both culprit and non-culprit vessel. The impairment of coronary flow is also demonstrated in known diabetic patients, suggesting to consider hyperglycemia an additional risk factor. We finally demonstrated for the first time a positive linear relationship between PGL and cTFC. |
| Keywords: | ACS acute coronary syndromes AMI acute myocardial infarction CAD coronary artery disease cTFC corrected TIMI frame count DM diabetes mellitus LAD left anterior descending PGL plasma glucose level pPCI primary percutaneous coronary intervention STEMI ST-elevation myocardial infarction TFC TIMI frame count TnI Troponin I WMSI Wall Motion Score Index Hyperglycemia Myocardial perfusion STEMI Primary percutaneous coronary intervention TIMI frame count |
| 本文献已被 ScienceDirect 等数据库收录！ | |