Factors associated with preservation of C-peptide levels at the diagnosis of type 1 diabetes |
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| Authors: | Agnieszka Szypowska Lidia Groele Marta Wysocka-Mincewicz Artur Mazur Lucyna Lisowicz Iwona Ben-Skowronek Joanna Sieniawska Bo?enna Klonowska Dorota Charemska Jolanta Nawrotek Irena Ja?owiec Artur Bossowski Klaudyna Noiszewska Beata Pyr?ak Izabela Rogozińska Mieczys?aw Szalecki |
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| Institution: | 1. Department of Pediatrics, Medical University of Warsaw, Poland;2. Department of Endocrinology and Diabetology, Children''s Memorial Health Institute, Warsaw, Poland;3. Faculty of Health Sciences, UJK, Kielce, Poland;4. II Department of Pediatrics, Pediatric Endocrinology and Diabetes, Medical Faculty University of Rzeszow, Poland;5. Department of Pediatric Endocrinology and Diabetology, Medical University of Lublin, Poland;6. Department of Clinical Pediatrics, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Provincial Specialist Children''s Hospital, Olsztyn, Poland;g. Endocrinology and Diabetology Ward, General District Hospital, Kielce, Poland;h. Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bia?ystok, Poland;i. Department of Pediatrics and Endocrinology, Medical University of Warsaw, Poland |
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| Abstract: | AimsThe level of C-peptide can identify individuals most likely to respond to immune interventions carried out to prevent pancreatic β-cell damage.The aim of the study was to evaluate factors associated with C-peptide levels at type 1 diabetes (T1D) diagnosis.MethodsThis study included 1098 children aged 2-17 with newly recognized T1D. Data were collected from seven Polish hospitals. The following variables were analyzed: date of birth, fasting C-peptide, HbA1c, sex, weight, height, pH at diabetes onset.ResultsA correlation was observed between fasting C-peptide level and BMI-SDS (p?=?0.0001), age (p?=?0.0001), and HbA1c (p?=?0.0001). The logistic regression model revealed that fasting C-peptide ≥0.7 ng/ml at diabetes diagnosis was dependent on weight, HbA1c, pH and sex (p?<?0.0001).Overweight and obese children (n?=?124) had higher fasting C-peptide (p?=?0.0001) and lower HbA1c (p?=?0.0008) levels than other subjects. Girls had higher fasting C-peptide (p?=?0.036) and higher HbA1c (p?=?0.026) levels than boys.ConclusionObese and overweight children are diagnosed with diabetes at an early stage with largely preserved C-peptide levels. Increased awareness of T1D symptoms as well as improved screening and diagnostic tools are important to preserve C-peptide levels. There are noticeable gender differences in the course of diabetes already at T1D diagnosis. |
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| Keywords: | Childhood Beta cells Body mass index Obesity Age |
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