Strain differences in mice in the development of tolerance to the anti-pentylenetetrazole effects of diazepam |
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| Authors: | S E File |
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| Affiliation: | Department of Pharmacology, The School of Pharmacy, University of London, Brunswick Square, London WC1N 1AX U.K. |
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| Abstract: | The development of tolerance to the protective effects of diazepam (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) were studied in 3 strains of mice. Significant tolerance developed to protection against myoclonic jerks induced by PTZ (90-100 mg/kg) by day 5 in Tuck No. 1 and by day 10 in C3H/HE and CD-1 mice. Tolerance developed to protection against tonic-clonic convulsions by day 10 in Tuck No. 1 mice and by day 30 in the other strains. Diazepam remained protective against tonic-clonic convulsions (but not against myoclonus) induced by threshold doses of PTZ for 30 days in all 3 strains. |
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| Keywords: | mice strain differences convulsions tolerance pentylenetetrazole diazepam |
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