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| 羟基吡啶酮促排铀和钚的研究进展 | |
| 引用本文： | 廖琪丽,胡文祥,周志明,王建营,程天民. 羟基吡啶酮促排铀和钚的研究进展[J]. 中国药物化学杂志, 2005, 15(1): 60-64 |
| 作者姓名： | 廖琪丽 胡文祥 周志明 王建营 程天民 |
| 作者单位： | 1. 总装备部军事医学研究所,北京,100101;重庆大学,化学化工学院,重庆,400044 2. 总装备部军事医学研究所,北京,100101 3. 重庆大学,化学化工学院,重庆,400044 4. 第三军医大学,复合伤研究所,重庆,400038 |
| 摘 要： | 铀和钚是锕系的两种放射性元素,广泛用于军事领域.现代战争中由于大范围使用贫铀弹,使贫铀中毒问题受到世界各国越来越多的关注.治疗铀、钚等重金属中毒的主要方法是使用络合剂将之排除,羟基吡啶酮由于其特殊的结构特点、高度的选择性络合能力以及显著的生理活性,成为促排领域的一大研究热点,本文对近年来羟基吡啶酮对铀、钚的促排研究概况做简要综述,并对其发展前景进行展望. |
| 关 键 词： | 药物化学 构效关系 综述 羟基吡啶酮 铀 钚 促排 络合剂 |
| 文章编号： | 1005-0108(2005)01-0060-05 |
Advances in the study on hydroxypyridinone chelating agents for uranium and plutonium |
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| LIAO Qi-li ,,HU Wen-xiang,ZHOU Zhi-ming,WANG Jian-ying,CHENG Tian-min. Advances in the study on hydroxypyridinone chelating agents for uranium and plutonium[J]. Chinese Journal of Medicinal Chemistry, 2005, 15(1): 60-64 | |
| Authors: | LIAO Qi-li HU Wen-xiang ZHOU Zhi-ming WANG Jian-ying CHENG Tian-min |
| Affiliation: | LIAO Qi-li 1,2,HU Wen-xiang1,ZHOU Zhi-ming2,WANG Jian-ying1,CHENG Tian-min3 |
| Abstract: | Uranium and plutonium are radioelements,which are widely used in the military area.The use of depleted uranium(DU)weapons makes all of us have to face the problem of DU toxicosis.Chelating agent administration is the chief method of the treatment of heavy metals overload.Because of the special structure,highly selective abilities and remarkable activities,hydroxypyridinones become the focus of the chelating area.The study of chelation on uranium and plutonium is summarized in this brief review.The development of hydroxypyridinone chelating agents is foreseeable. |
| Keywords: | medicinal chemistry SRA review hydroxypyridinone uranium plutonium chelation chelating agents |
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