In vivo evaluation of substituted 2,3-diaryl acrylophenone amide derivatives as anti-implantation agents |
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| Authors: | Atul Gupta Govind Keshri M. M. Singh Suprabhat Ray |
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| Affiliation: | (1) Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, 226001, India;(2) Endocrinology Division, Central Drug Research Institute, Lucknow, 226001, India |
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| Abstract: | A series of substituted 2,3-diaryl acrylophenone amide derivatives was evaluated for their anti-implantation activity in mature female Sprague-Dawley rats. Compounds 11, 14, 15, and 19 showed significant activity in preventing implantation in rats at 10 mg kg−1. |
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| Keywords: | Anti-implantation agents Estrogen receptors Estrogen agonists Estrogen antagonists Fertility regulation Drug research |
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