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Tumor vascular disrupting agent 5,6‐dimethylxanthenone‐4‐acetic acid inhibits platelet activation and thrombosis via inhibition of thromboxane A2 signaling and phosphodiesterase
Authors:S. H. Zhang  Y. Zhang  J. Shen  S. Zhang  L. Chen  J. Gu  J.S. Mruk  G. Cheng  L. Zhu  S. P. Kunapuli  Z. Ding
Affiliation:1. Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, , Shanghai, China;2. Cyrus Tang Hematology Center, Soochow University, , Suzhou, China;3. Key Laboratory of Glycoconjuate Research, Ministry of Public Health and Gene Research Center, Fudan University Shanghai Medical College, , Shanghai, China;4. Department of Internal Medicine, University of Kansas School of Medicine, , Witchita, KS, USA;5. Thoracic Oncology Research Laboratory, University of Pennsylvania, , Philadelphia, PA, USA;6. Department of Physiology, Sol Sherry Thrombosis Research Center, Temple University School of Medicine, , Philadelphia, PA, USA
Abstract:
Keywords:antiplatelet agents  antitumor agents  DMXAA  phosphodiesterase inhibitors  TXA2
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