Effects of third ventricle injection of prostaglandins on gonadotropin secretion in goldfish,Carassius auratus |
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Authors: | RE Peter R Billard |
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Institution: | Department of Zoology, University of Alberta, Edmonton, Alberta T6G 2E9, Canada |
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Abstract: | The effects of injection of prostaglandin (PG) E1, PGE2, and PGF2α into the third ventricle on serum gonadotropin (GTH) concentrations in the goldfish were tested. Blood samples were taken at 30 min postinjection for radioimmunoassay of serum GTH. PG dosages of 0.5 and 1.0 μg were ineffective. However, PGE2 and PGF2α at the 2.0-μg dosage significantly suppressed serum GTH. PGE1 at a 2.0-μg dosage had no effect. There were no effects on serum GTH when 2.0 μg of PGE1, PGE2, or PGF2α were injected intraperitoneally. The results indicate that PGE2 and PGF2α suppress gonadotropin secretion by some action, presumably on the hypothalamus. However, action of PGE2 and PGF2α by diffusion from the site of injection to some other brain site or the pituitary cannot be eliminated in the present study. |
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