Comparison of effects of pitavastatin and atorvastatin on glucose metabolism in type 2 diabetic patients with hypercholesterolemia |
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Authors: | Tomoya Mita Shiho Nakayama Hiroko Abe Masahiko Gosho Hitoshi Iida Takahisa Hirose Ryuzo Kawamori Hirotaka Watada |
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Affiliation: | 1. Department of Metabolism and Endocrinology, Tokyo University of Science, , Tokyo, Japan;2. Center for Molecular Diabetology, Tokyo University of Science, , Tokyo, Japan;3. Graduate School of Engineering, Tokyo University of Science, , Tokyo, Japan;4. Center for Therapeutic Innovations in Diabetes, Tokyo University of Science, , Tokyo, Japan;5. Sportology Center, Tokyo University of Science, , Tokyo, Japan;6. Center for Beta Cell Biology and Regeneration, Juntendo University Graduate School of Medicine, Tokyo University of Science, , Tokyo, Japan |
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Abstract: | Aims/IntroductionThe distinct effects of different statins on glycemic control have not been fully evaluated. In this open‐label, prospective, cross‐over clinical trial, we compared the effects of pitavastatin and atorvastatin on glycemic control in type 2 diabetic patients with hypercholesterolemia.Materials and MethodsA total of 28 Japanese type 2 diabetics with hypercholesterolemia treated with rosuvastatin (2.5 mg/day) for at least 8 weeks were recruited to this quasi‐randomized cross‐over study. At study entry, the patients assigned to sequence 1 received pitavastatin (2 mg/day) for 12 weeks in period 1 and atorvastatin (10 mg/day) for another 12 weeks in period 2, whereas patients assigned to sequence 2 received atorvastatin (10 mg/day) for 12 weeks in period 1 and pitavastatin (2 mg/day) for another 12 weeks in period 2. Blood samples were collected at three visits (baseline, after 12 and 24 weeks).ResultsLipid control was similar in both statins. The difference in glycated hemoglobin between pitavastatin and atorvastatin treatments was −0.18 (95% confidence interval −0.34 to −0.02; P = 0.03). Compared with atorvastatin, pitavastatin treatment significantly lowered the levels of glycoalbumin, fasting glucose and homeostasis model assessment of insulin resistance.ConclusionsOur results showed that treatment with pitavastatin had a more favorable outcome on glycemic control in patients with type 2 diabetes compared with atorvastatin. This trial was registered with UMIN (no. 000003554). |
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Keywords: | 3‐Hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitor Type 2 diabetes mellitus, Hypercholesterolemia |
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