确证试验评价梅毒患者感染现状的意义

目的 分析梅毒患者的感染现状与治疗疗效的关系.方法 用苍白密螺旋体(梅毒密螺旋体)被动血凝试验(TPPA)法确证抗梅毒抗体阳性,并测定它们的梅毒心磷脂反应素(RPR)滴度,分别对比RPR阳性组和阴性组血清与荧光密螺旋体抗体吸收试验(FTA-ABS)的检测结果;追踪检测梅毒感染者治疗的RPR滴度与FTA-ABS的抗体强度.结果 RPR阳性组与RPR阴性组的FTA-ABS阳性检出率分别为77.5%与37.5%,差异有统计学意义(X~2=24.47,P<0.05);随着RPR滴度的降低,FTA-ABS的阳性检出率也降低;经过治疗RPR滴度下降的病例,其FTA-ABS检测的抗体强度也随之下降.结论 观察梅毒治疗疗效,在监测RPR的下降程度时,也应检测FTA-ABS,两者均为阴性时再停止治疗.

Significance of Confirmation Test of Serum for Syphilis Patients

OBJECTIVE To analyze the relationship between the infection status and therapentic efficacy among syphilis patients. METHODS The positive samples with Treponema pallidum passive agglutinatim (TPPA) test and titers of rapid plasma reagin test for syphilis (RPR) were detected, compared the results of fluorescence treponemal antibody absorption test for syphilis (FTA-ABS) between the RPR positives and RPR negatives and test the density of RPR and FTA-ABS after therapy. RESULTS There was significant difference between the positive and the negatives of RPR (P<0.005). With the descent of density of RPR, the positive rate of FTA-ABS was decreased. With the degree of RPR descended after therapy, the density of FTA-ABS was also descended at the same time. CONCLUSIONS To observe the curative effect, FTA-ABS should be tested for the descent of RPR. When RPR and FTA-ABS are negative, the therapy can be stopped.