Conversion of chronic atrial fibrillation to sinus rhythm with combined propranolol and quinidine treatment |
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| Authors: | S Stern |
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| Affiliation: | 1. Logy.AI, Machine Learning Research Division, Indian Institute of Technology Bhilai, Raipur India;2. Genome engineering laboratory, University of Westminster, London W1W 6UW, United Kingdom;3. School of Life Sciences, University of Bedfordshire, Park Square, Luton LU1 3JU, United Kingdom;1. Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China;2. Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, CA, USA;3. Department of Pathology, Case Western Reserve University, Cleveland, OH, USA;4. Department of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX, USA;5. Center for Medical Innovation, Department of Biosciences and Nutrition at Novum, Karolinska Institute, Stockholm, Sweden;1. Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, UK;2. Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, St Mary’s Hospital Campus, Imperial College London, London, UK;3. Department of Clinical and Experimental Medicine, University of Surrey, Guildford, Surrey, UK |
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| Abstract: | A new method of drug treatment for the conversion of chronic atrial fibrillation to sinus rhythm is presented. This consists of pretreatment with propranolol (Inderal), followed by the addition of small doses of quinidine. Eighteen conversions were attempted by this method, and in only 3 was sinus rhythm not obtained. The successes included 5 patients who had previously required very large doses of quinidine alone in order to achieve sinus rhythm.The combination of propranolol and quinidine in small doses appears to be a simple, safe, and effective method for the achievement of sinus rhythm in patients with chronic atrial fibrillation. |
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