改良FOLFOX-6方案治疗晚期胃癌的临床观察

目的 观察奥沙利铂(OXA)联合亚叶酸钙(CF)、氟脲嘧啶(5-Fu)治疗晚期胃癌的近期疗效和毒副反应.方法 24例均接受奥沙利铂85 mg/m2静脉滴注3 h,d1;CF 200 mg/m2静脉滴注2 h,给予5-Fu 400 mg/m2静脉推注,d1;后续5-Fu 2 000 mg/m2静脉持续输注约44 h.14 d为1周期,应用2周期后判定疗效.结果 完全缓解(CR)2例,部分缓解(PR)10例,总有效率为50%.24例共完成99个周期化疗,骨髓抑制为主要毒副反应,白细胞减少达90.9%;其次为胃肠道反应发生率87.4%,腹泻则为45.5%;另外周围神经毒性高达51.5%.结论 OXA联合CF 5-Fu治疗晚期胃癌有较好疗效,毒副反应可耐受,值得临床进一步推广应用.

Clinical Study of Modified FOLFOX-6 Regiment in the Treatment of Patients with Advanced Gastric Carcinoma

Objective To evaluate the efficacy and safety of oxaliplatin combined with 5-fluorouracil/calcium folinate in the treatment of patients with advanced gastric carcinoma.Methods Oxaliplatin 85 mg/m2 iv infusion for 3 h,d1,CF 200 mg/m2 iv infusion for 2 h followed by 5-Fu 400 mg/m2 iv,d1,and 5-Fu 2 000 mg/m2 iv infusion for 44 h,repeated every 2 weeks.Tumor assessment was done after 2 cycles.Results 24 patients entered this study,99 cycles were evaluated for the toxicity:CR 2 cases,PR 10 cases,SD 9 cases,PD 3 cases.The overall response rate was 50%.The main adverse effects were myelosuppression.Neutropenia was 90.9%,nausea/vomiting 87.4%,diarrhea was 45.5%,neurosensory toxicity was 51.5%.Conclusions This regimen of oxaliplatin combined with 5-Fu/CF was more effective for the treatment of advanced gastric carcinoma,the toxicity was mild and tolerable,which is worthy of further clinical study.