1217例肾活检患者临床与病理资料分析

目的 了解行肾穿刺活检患者的流行病学特点及病理类型与临床表现间的关系.方法 回顾性分析1217例行肾活检者的性别、年龄、病理类型及临床表现等相关资料.结果 1217例患者行肾活检时的平均年龄为（30.86±13.41）岁,男性612例（50.3％）,女性605例（49.7％）.男性占本组原发性肾小球疾病（PGN）的52.2％,继发性肾小球疾病（SGN）的39.0％.肾脏病患者的高发年龄段为20 ～39岁（50.9％）.本组患者最常见的临床表现为肾病综合征（NS）610例（50.1％）,其余分别为尿检异常型（Uab）453例（37.2％）,反复发作性肉眼血尿型（rGH）89例（7.3％）,慢性肾衰竭（CRF）31例（2.5％）,急性肾损伤（AKI） 12例（1.0％）,高血压型（HT）11例（0.9％）,急性肾炎综合征（ANS）8例（0.7％）,孤立性肉眼血尿型（iGH）3例（0.2％）.原发性肾小球疾病以系膜增生性肾炎（MsPGN）,继发性肾小球疾以狼疮性肾炎（LN）为主要病理类型.本组患者中各临床分型均以系膜增生性肾炎为主要病理类型,除系膜增生性肾炎外,肾病综合征以MN,Uab以IgAN为主要病理类型.结论 原发性肾小球疾病是徐州地区最常见的肾脏疾病,男性、青壮年是高发人群,系膜增生性肾炎是最常见病理类型,肾病综合征是最常见的临床表现.

Clinical epidemiology of renal diseases in Xuzhou area based on 1217 renal biopsy data

Objective To summarize the clinical epidemiology and correlation between pathology and clinical features of all the renal biopsy cases in the Affiliated Hospital of Xuzhou Medical University. Method To retrospectively investigate the clinico-patbological date in 1217 cases having underwent renal biopsy in the Affiliated Hospital of Xuzhou Medical University. Demographic data were obtained from all patients. Results The mean age of the whole group patients was 30.86 ±13.41 （ 6 - 75 ） years, 50.3% patients were male and 49.7% were female. Of the 1048 patients with Primary glomerular disease（PGD） 52.2% were male; with the secondary glomerulonephritis （SGN）, male amounted to 39%. A high incidence rate（50.9% ） of this group patients occurred at the age from 20 to 39 years. In total renal patients biopsied, nephritic syndrome was the most frequent clinical manifestation （50. 1% ）. In IgA nephropathy （IgAN）, the most frequent clinical manifestations was urinary abnormalities （Uab） （43 % ） ;while mesangial proliferative glomerulonephritis（MsPGN） ,membranous nephropathy（MN） ,focal segmental glomerulosclerosis（FSGS） ,minimal change disease（MCD） were frequently showed as NS. Conclusion PGD was the most common renal disease. Male and adolescent were predominant in this group of patients. MsPGN was the most frequent pathology type, while NS was the most frequent clinical syndrome.