晚期肺癌合并肺部感染的临床研究

目的探讨晚期肺癌合并肺部感染的临床特点。方法对近4年收治的130例晚期肺癌合并肺部感染病例的临床资料进行分析。结果本组患者年龄≥60岁、性别为男性、住院天数≥15天、合并基础疾病、外周血白细胞计数<4×109/L、低蛋白血症者易并发肺部感染。当病人出现中度以上发热、血氧饱和度降低时要高度警惕可能合并肺部感染。血CRP、PCT升高可作为肺部感染的炎症预测指标。革兰氏阴性杆菌(67.23%)是肺部感染的最常见致病菌,存在多药耐药,根据药敏试验结果及时调整抗生素的使用。结论晚期肺癌合并肺部感染存在多种危险因素,应加强预防,要重视病原学检测及药敏试验,合理使用抗生素。

Clinical study of advanced lung cancer patients complicated with lung infection

Objective To investigate the clinical features of advanced lung cancer patients complicated with pulmonary infection.Methods The clinical data of 130 advanced lung cancer patients complicated with lung infection in the past 4 years were retrospectively analyzed.Results All patients were male and older than 60 male.Their duration of hospital stay was more than 15 days.These patients were complicated with underlying diseases and their WBC was less than 4×109/L.The patients with hypoproteinemia were easily infected.When the patients had moderate fever and blood oxygen saturation decreased,they were probably complicated with pulmonary infection.The increase of CRP and PCT might be as inflammatory predictors of lung infection.The most common pathogens were Gram-negative bacilli（67.23%）,which had multidrug resistance.The use of antibiotics should be based on the results of susceptibility testing.Conclusion There are various risk factors of advanced lung cancer patients,which should strengthen prevention and pay more attention.Besides,the use of antibiotics should be rational.