急性冠脉综合征患者血清高敏C反应蛋白、基质金属蛋白酶-9与冠状动脉病变程度的相关性研究

目的 探讨急性冠脉综合征患者血清高敏C反应蛋白（hs-CRP）、基质金属蛋白酶-9（MMP-9）与冠状动脉病变程度的关系.方法 将88例急性冠脉综合征患者依据冠状动脉造影结果分为单支病变组（30例）、双支病变组（28例）和多支病变组（30例）,并选择同期冠状动脉造影检查正常者32例为对照组,比较各组hs-CRP、MMP-9的差异,运用Syntax评分评价急性冠脉综合征患者冠状动脉病变程度,通过多元逐步回归分析Syntax评分与各临床资料的相关性.结果 急性冠脉综合征患者血清hs-CRP、MMP-9水平明显高于对照组,并且随着冠状动脉病变严重程度的增加,hs-CRP、MMP-9水平逐渐升高（P＜0.05）.Pearson相关分析显示,hs-CRP与MMP-9呈正相关（r =0.438,P＜0.05）.多元逐步回归分析提示,Syntax评分与hs-CRP、MMP-9水平呈正相关（r分别为0.41和0.57,P＜0.05）.结论 急性冠脉综合征患者血清hs-CRP、MMP-9水平与冠状动脉病变程度相关,冠状动脉病变程度越重血清中hs-CRP、MMP-9的水平越高.

The relationship between serum hs-CRP, MMP-9 levels and severity of coronary artery lesion in patients with acute coronary syndrome

ObjectiveTo explore the relationship between the levels of hypersensitive C-reactive protein（ hs-CRP）, matrix metalloproteinase-9 （MMP-9）and severity of coronary artery lesions in patients with acute coronary syndrome （ACS）. Methods 88 patients being definitely diagnosed ACS were enrolled. According to the results of vascular lesions ensured by CAG, the patients were divided into single- vessel group （ n = 30） , double-vessel group （ n = 28 ） , multi-vessel group （ n = 30） respectively. At the same time ,32 patients hospitalized with a normal coronary angiography were for the control group. Differences of hs-CRP and MMP-9 levels among each group were compared. ACS patients were scored through syntax method, the relationship between syntax score and clinical data was evaluated through the multiple liner regression. Results The hs-CRP, MMP-9 levels in ACS were significantly higher than the control group （ P 〈 0.05 ） , and there was an increasing trend according with the coronary artery lesion degree. Pearson correlation analysis concluded that hs-CRP was associated with the MMP-9 （ r = 0.44, P 〈 0.05 ） , and multiple linear regression analysis manifested that there was a relevance between syntax score and both serous hs-CRP and MMP-9 in ACS patients（ the partial correlation coefficient were 0.41,0.57 respectively ,P 〈 0.05）. Condusion In patients with acute coronary syndrome,there was a correlation between hs-CRP, MMP-9 and the severity of coronary artery disease. The more severe of coronary lesion, the higher level of both serous hs-CRP and MMP-9.