| 阿立哌唑对利培酮所致高催乳素血症的疗效 |
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| 引用本文： | 陈景旭,王宁,卞清涛,王绍礼,刘艳红,张向阳.阿立哌唑对利培酮所致高催乳素血症的疗效[J].临床精神医学杂志,2009,19(2). |
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| 作者姓名： | 陈景旭 王宁 卞清涛 王绍礼 刘艳红 张向阳 |
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| 作者单位： | 北京回龙观医院,100096 |
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| 摘 要： | 目的:探讨阿立哌唑治疗利培酮所致高催乳素血症的有效性和安全性。方法:对19例利培酮所致高催乳素血症的男性精神分裂症患者,合并阿立哌唑10 mg/d。分别于治疗前、治疗2、4、8周检测血清催乳素水平;在治疗前、治疗8周评定阳性与阴性症状量表(PANSS)、临床总体印象量表-疾病严重度(CGI-S)、Barnes锥体外系不良反应量表(SAS)、Barnes静坐不能量表(BAS)和UKU不良反应量表(UKU)。结果:治疗4周催乳素水平显著下降(P<0.001),而治疗4周与治疗8周催乳素水平差异无显著性(P>0.05);研究结束时,所有患者催乳素水平下降超过50%,其中6例降至正常,5例患者催乳素相关症状均有改善;治疗前后PANSS、CGI-S、BAS和SAS评分差异无显著性(P>0.05)。结论:阿立哌唑可有效治疗利培酮所致的高催乳素血症,不良反应少。
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| 关 键 词： | 精神分裂症 阿立哌唑 利培酮 催乳素 |
Efficacy of aripiprazole treatment for risperidone-induced hyperprolactinemia |
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| CHEN Jing-xu,WANG Ning,BIAN Qing-tao,WANG Shao-li,LIU Yan-hong,ZHANG Xiang-yang.Efficacy of aripiprazole treatment for risperidone-induced hyperprolactinemia[J].Journal of Clinical Psychological Medicine,2009,19(2). |
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| Authors: | CHEN Jing-xu WANG Ning BIAN Qing-tao WANG Shao-li LIU Yan-hong ZHANG Xiang-yang |
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| Institution: | CHEN Jing-xu,WANG Ning,BIAN Qing-tao,WANG Shao-li,LIU Yan-hong,ZHANG Xiang-yang.Beijing Huillongguan Hospital,Beijing 100096,China. |
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| Abstract: | Objective:To explore the efficacy and safety of adjunctive treatment with aripiprazole on hyperprolactinemia induced by risperidone. Method:19 male schizophrenic patients with hyperprolactinemia induced by risperidone received 10 mg/d aripiprazole for adjunctive treatment.Serum prolactin levels were measured before treatment and 2,4 and 8 weeks after treatment.Positive and negative symptom scale(PANSS),clinical global impression scale-sevetity(CGI-S),Simpson-Angus scale(SAS),Barnes-Akathisia scale and Udval... |
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| Keywords: | schizophrenia aripiprazole risperidone prolactin |
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