| 骨碎补对链霉素耳毒性解毒作用的实验研究 |
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| 引用本文： | 戴小牛,童素琴,贾淑萍,陶艳梅. 骨碎补对链霉素耳毒性解毒作用的实验研究[J]. 东南大学学报(医学版), 2000, 19(4): 248-249 |
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| 作者姓名： | 戴小牛 童素琴 贾淑萍 陶艳梅 |
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| 作者单位： | 南京铁道医学院生理学教研室，江苏 南京 210009 |
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| 摘 要： | 目的探讨骨碎补对链霉素耳毒性的解毒作用。方法肌肉注射链霉素(300mg·kg-1)15d制成豚鼠耳聋模型，其中部分动物同时用100％骨碎补液灌胃(5ml·kg-1)。采用全耳蜗基底膜铺片技术，在光镜下计数毛细胞，并计算毛细胞损伤百分率。结果骨碎补液可使链霉素所致耳蜗一回和二回毛细胞的损伤减轻。结论骨碎补对链霉素耳毒性有一定的解毒作用。
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| 关 键 词： | 骨碎补；链霉素；耳毒性；豚鼠 |
| 文章编号： | 1001-7275(2000)04-0248-02 |
| 修稿时间： | 2000-03-29 |
Gusuibu Attenuates the Ototoxicity by Streptomycin |
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| DAI Xiao-niu,TONG Su-qin,JIA Shu-ping,TAO Yan-rnei. Gusuibu Attenuates the Ototoxicity by Streptomycin[J]. Journal of Southeast Univ: Medical Sci Ed, 2000, 19(4): 248-249 |
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| Authors: | DAI Xiao-niu TONG Su-qin JIA Shu-ping TAO Yan-rnei |
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| Abstract: | Objective The purpose of the present study was to analyze the effect of Gusuibu on the ototoxicity by streptomycin. Methods A deafness model was established in 30 guinea pigs by streptomycin (300 rmg· kg-1,i.m.),in which 17were used as experimental group(32 ears) and 13 as controls( 18 ears). The experimental animals were administrated with 100% Gusuibu solution(5 ml· kg-1 )orally. Cochlear pathology was assessed by surface preparation technique. Detail counts of hair cells were recorded under light microscope and analyzed statistically. Result C usuibu decreased the loss of outer hair cells in the lirst and second coils. Conclusion Gusuibu may attenuate the ototoxicity by streptomycin. |
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| Keywords: | Rhizoma Drynaiae (Gusuibu ) streptomycin ototoxicity guinea pi |
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