妊娠期高血压病患者血管活性因子水平的变化

目的：探讨妊娠期高血压病患者血浆神经肽Y（NPY）、降钙素基因相关肽（CGRP）、可溶性血管细胞黏附分子-1（sVCAM-1）及可溶性细胞间黏附分子-1（sICAM-1）水平的变化与患者发病的关系。方法：：32例非孕妇女、30例正常孕妇（对照组）及30例妊娠期高血压病患者的血浆NPY、CGRP含量均采用放射免疫分析;血浆sVCAM-1和sICAM-1采用酶联免疫分析法测定。结果：本文结果显示,对照组CGRP水平较非孕妇女组升高显著（P〈0.05）;妊娠期高血压病治疗前组CGRP水平较对照组降低非常显著（P均〈0.01）;经治疗水平明显升高,但与对照组比较仍存在显著差异（P〈0.05）。NPY水平对照组较非孕妇女组升高无显著性（P〉0.05）;治疗前组NPY水平较对照组升高非常显著（P〈0.01）;经治疗水平已明显下降,与对照组比较差异无显著性（P〉0.05）。sVCAM-1水平对照组与非孕妇女组比较无显著性差异（P〉0.05）;治疗前组水平较对照组升高显著（P〈0.05）;经治疗水平明显下降,较对照组略高,但已无显著性差异（P〉0.05）。sICAM-1水平显示对照组及非孕妇女组略升高,但无显著性差异（P〉0.05）;治疗前组较对照组略高,但也无显著性差异（P〉0.05）;经治疗sICAM-1水平与对照组比较亦无显著性差异（P〉0.05）。相关分析结果显示,CGRP含量血浆浓度与其平均动脉压呈显著负相关（r=-0.5812,P〈0.01）,而NPY含量则显著高于对照组妇女,并随病情的加重而上升,与其平均动脉压呈显著正相关（r=0.6097,P〈0.01）。结论：妊娠期高血压病患者血浆NPY、CGRP及sVCAM-1三项指标的测定对于了解和认识其发病机理及预估病情有帮助。

Changes of Plasma Vasoactive Factors Levels in Patients with Pregnancy Induced Hypertension (PIH)

Objective To study the changes of plasma levels of neuropeptide Y（NPY）,calcitonin-gene related peptide（CGRP）,soluble vascular cell adhesion molecule-1（sVCAM-1） and soluble intercellular adhesion molecule-1（sICAM-1） in patients with PIH.Methods Plasma NPY,CGRP（with RIA） and sVCAM-1,sICAM-1（with ELISA） levels were determined in ① 32 non-pregnant women ② 30 normal pregnant women and ③ 30 pregnant women with PIH,both before and after a course of treatment.Results The plasma CGRP levels in normal pregnant women were significantly higher than those non-pregnant women（P〈0.05）.The plasma CGRP levels in patients with PIH before treatment were significantly lower than those in normal pregnant women.After a course of treatment,the levels rose much but were still significantly lower than those in normal pregnant women（P〈0.05）.The plasma NPY levels were about the same in normal pregnant and non-pregnant women.However,the plasma levels of NPY in patients with PIH were very significantly,higher than those in normal pregnant women（P〈0.01）.After treatment,the levels dropped to about the same in normal pregnant women.The same was true with plasma sVCAM-1 levels.With sICAM-1,the plasma levels were not much different among the three groups of subjects studied.Plasma CGRP levels were significantly negatively correlated with the mean arterial blood pressure（r=-0.5812,P〈0.01）,but plasma NPY levels were significantly positively correlated with the mean arterial pressure（r=0.6097,P〈0.01）.Conclusion Determination of plasma CGRP,NPY and sVCAM-1 levels were of clinical and prognostic importance in patients with PIH.