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| 中药拮新康对K562/A02细胞内阿霉素积聚浓度的影响 | |
| 引用本文： | 秦群,谢兆霞,黄程辉,李新中,万永艳. 中药拮新康对K562/A02细胞内阿霉素积聚浓度的影响[J]. 湖南中医药大学学报, 2005, 25(5): 18-20 |
| 作者姓名： | 秦群 谢兆霞 黄程辉 李新中 万永艳 |
| 作者单位： | 1. 中南大学湘雅医院,湖南,长沙,410008 2. 中南大学湘雅三医院,湖南,长沙,410013 3. 中南大学药学院,湖南,长沙,410013 |
| 基金项目： | 湖南省自然科学基金项目（编号03JJY5013）. |
| 摘 要： | 目的探讨中药拮新康对K562／A02细胞内阿霉素积聚浓度的影响。方法采用高效液相色谱法测定细胞内阿霉素（ADM）浓度。结果10％拮新康血清加ADM组较10％正常血清加ADM组细胞内ADM浓度明显升高（P〈0．05）。结论拮新康能增加ADM在K562／A02细胞内的积聚浓度，逆转K562／A02细胞耐药。 |
| 关 键 词： | 拮新康 多药耐药 K562／A02阿霉素 |
| 文章编号： | 1000-5633（2005）05-0018-03 |
| 收稿时间： | 2005-04-27 |
| 修稿时间： | 2005-04-27 |
Effect of Jie Xin Kang on Intracellular Adriamycin Accumulation in K562/A02 Cell Line |
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| Qin Qun , Xie Zhaoxia ,Huang Chenghui ,et al. Effect of Jie Xin Kang on Intracellular Adriamycin Accumulation in K562/A02 Cell Line[J]. Journal of Traditional Chinese Medicine University of Hunan, 2005, 25(5): 18-20 | |
| Authors: | Qin Qun Xie Zhaoxia Huang Chenghui et al |
| Affiliation: | 1. Xiangya Hospital of Central South University, Changsha 410008; 2.The Third Xiangya Hospital of Central South University, Changsha 410013 |
| Abstract: | Objective To study the effect of Chinese medicine Jie Xin Kang(JXK) on the intracellular adriamycin(ADM) accumulation in K562/A02 cell line.Methods The intracellular ADM concentration was assayed by HPLC.Results The celleular ADM concentration of 10% serum containing JXK adding ADM group was significantly higher than that of 10% normal serum adding ADM group(P<0.05)after treating with different drugs for 1 and 3 hours.Conclusions JXK can improve the intracellular ADM accumulation in K562/A02 cell line.and consequently reverse MDR. |
| Keywords: | Jie Xin Kang multidrug resistance intracellular concentration |
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