| 新生儿乙型肝炎疫苗免疫后13年效果观察 |
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| 引用本文： | 吴维寿,孙超美,姜铭波,徐元,张国华,刘崇柏,曹惠霖,林曦敏,徐志一.新生儿乙型肝炎疫苗免疫后13年效果观察[J].中华实验和临床病毒学杂志,2001,15(3):239-241. |
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| 作者姓名： | 吴维寿 孙超美 姜铭波 徐元 张国华 刘崇柏 曹惠霖 林曦敏 徐志一 |
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| 作者单位： | 上海市南市区卫生防疫站 |
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| 摘 要： | 目的 研究乙型肝炎的远期免疫效果。方法 采用单纯随机方法连续13年对1986年出生并接种乙型肝炎疫苗的儿童进行隔年随访，采血检测HBsAg、抗-HBs、抗-HBc。结果 13年间HBsAg阳性率在0.46%-0.97%之间，未随免疫时间的延长而上升，乙型肝炎疫苗的远期保护效果为81.67%，与近期免疫效果相当。结论 免疫后13年仍无需加强免疫。
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| 关 键 词： | 病毒性肝炎疫苗 乙型肝炎表面抗原 新生儿 免疫 |
| 修稿时间： | 2000年8月8日 |
Long-term efficacy of vaccination against hepatitis B in newborns: 13 years' follow-up |
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| WU Weishou,SUN Chaomei,JIANG Mingbo,et al..Long-term efficacy of vaccination against hepatitis B in newborns: 13 years' follow-up[J].Chinese Journal of Experimental and Clinical Virology,2001,15(3):239-241. |
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| Authors: | WU Weishou SUN Chaomei JIANG Mingbo |
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| Institution: | Shanghai Huangpu District Center for Disease Control and Prevention, Shanghai 200011, China. |
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| Abstract: | Objective To evaluate long term efficacy of hepatitis B vaccination in newborns.Methods In the past 13 years we followed up the children who had been immunized with hepatitis B vaccine at birth in 1986 every other year. At each follow up visit, every child was tested for HBsAg, anti HBs and anti HBc.Results HBsAg positive rate of these birth cohort was low (range between 0 46% and 0 98%) during 13 years' follow up. Long term efficacy of the vaccination in preventing HBsAg carriage was confirmed.Conclusion Thirteen years later no booster was after needed. |
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| Keywords: | Viral hepatitis vaccines Hepatitis B surface antigens Long term efficacy |
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