| 河北地区汉族人血管紧张素转换酶基因与糖尿病肾病的相关性研究 |
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| 引用本文： | 张艳玲,李英,顾连方.河北地区汉族人血管紧张素转换酶基因与糖尿病肾病的相关性研究[J].中华肾脏病杂志,1999,0(1):40-42. |
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| 作者姓名： | 张艳玲 李英 顾连方 |
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| 作者单位： | 河北医科大学第三医院肾内科 |
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| 摘 要： | 目的探讨血管紧张素转换酶（ＡＣＥ）基因与糖尿病肾病（ＤＮ）发病的关系。方法用ＰＣＲ方法检测１４９例ＮＩＤＤＭ患者及１００例正常对照的ＡＣＥ基因型。结果（１）ＡＣＥ基因型及等位基因构成比在正常对照组和ＮＩＤＤＭ组间无统计学差异；（２）ＤＤ基因型及Ｄ等位基因频率在ＤＮ组（０２７）显著高于非ＤＮ组（００９）。结论ＡＣＥ基因多态性与ＤＮ发病有关。
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| 关 键 词： | 血管紧张素转换酶基因 糖尿病肾病 |
Relationship between angiotensin I converting enzyme gene I/D polymorphism and diabetic
nephropathy in NIDDM in the hans of Hebei province |
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| ZHANG Yanling,LI Ying,GU
Lianfang,et al..Relationship between angiotensin I converting enzyme gene I/D polymorphism and diabetic
nephropathy in NIDDM in the hans of Hebei province[J].Chinese Journal of Nephrology,1999,0(1):40-42. |
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| Authors: | ZHANG Yanling LI Ying GU
Lianfang |
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| Institution: | ZHANG Yanling,LI Ying,GU
Lianfang,et al.Department of nephrology,Third Hospital,Hebei Medical University,Shijiazhuang
050051 |
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| Abstract: | Objective To clarify if ACE gene I/D polymorphism attributes to the
development of diabetic nephropathy in NIDDM.Methods ACE genotypes were detected with
PCR amplification in 149 patients with NIDDM and 100 controls who were hans from Hebei
province.Results (1)The genotype distribution was not significantly different between 149
NIDDM and 100 normal controls;(2)The DD genotype frequency was significently higher in DN
group(027)than that in normal albuminuria(009)(P<001). Conclusion The ACE gene I/D
polymorphism attributes to the development of diabetic nephropathy in NIDDM in the hans of
Hebei province. |
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| Keywords: | Angiotensin converting enzyme geneDiabetic nephropathy |
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