Ophthalmoplegia with diffuse large B cell lymphoma: vital differential diagnosis

Ophthalmoplegia is an unusual finding in diffuse large B cell lymphoma. This report describes the case of a 72-year old male patient who presented with ophthalmoplegia but no gross neurological manifestations and an isolated mass in the left upper thigh. His ophthalmoplegia improved from his first cycle of systemic and intrathecal chemotherapy, his thigh mass effusion spontaneously resolved, and his laboratory tests also showed improvement. The patient remained well, though weak, for several months with no other neurological signs. He subsequently died from clinically diagnosed pulmonary embolism.