低氮低热量肠外营养支持对胰腺癌患者术后恢复的影响

目的 观察低氮低热量肠外营养支持对胰腺癌患者术后早期恢复的影响.方法 采用前瞻、随机、对照的方法,将符合入选标准的胰腺癌术后患者60例,随机分为对照组(n=30)和研究组(n=30),分别给予传统肠外营养(热量每日117.6 kJ/kg体重,氮每日0.2 g/kg体重)和低氮低热量营养(热量每1375.6 kJ/kg体重,氮每日0.1 g/kg体重),观察输营养液过程中血红蛋白、白细胞、肝肾功能、血糖水平、氮平衡的变化及感染相关并发症等.结果 两组患者术后1、4、7 d的血红蛋白、白细胞、肝.肾功能、氮平衡等指标差异均无统计学意义(P>0.05);对照组的空腹血糖及输液后2 h血糖水平均显著高于研究组(P<0.05),静脉炎的发生率也明显高于研究组(P<0.05).结论 胰腺癌术后早期给予低氮低热量PN支持,在不影响患者营养状态的情况下,很好的控制了血糖水平及其相关并发症,是一种安全有效的治疗方法.

Effects of hypocaloric and lower nitrogen parenteral nutrition support on postoperative recovery of the patients with pancreatic cancer

Objective To evaluate the effect of hypocaloric and lower nitrogen parenteral nutri-tion support on early recovery after operation in the patients with pancreatic cancer. Methods In a pro-spective, randomized and controlled trial, 60 patients with pancreatic cancer after surgical operation were randomly divided into control group (n = 30) and study group(n = 30), subjected to traditional parenteral liver and renal functions, blood glucose level, nitrogen balance and infection related complications were ob-served during nutrition fluid transfusion after operation. Results There was no significant difference in he-moglobin, leukocytes,liver and renal functions and nitrogen balance between control group and study group (P > 0.05). The fasting blood glucose and glucose levels, and the incidence of phlebitis after transfusion were significantly higher in the control group than in the study group (P < 0.05). Conclusion The use of hypecaloric and lower nitrogen parenteral nutrition had controlled the blood glucose levels and the related complications well without influencing the nutritional status of the patients.