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从喜树叶中碱法提取喜树碱新工艺
引用本文:王洋,于涛,张玉红,祖元刚. 从喜树叶中碱法提取喜树碱新工艺[J]. 医学教育探索, 2001, 0(10): 882-884
作者姓名:王洋  于涛  张玉红  祖元刚
作者单位:王洋(东北林业大学森林植物生态学开放研究实验室,黑龙江哈尔滨150040)      于涛(东北林业大学森林植物生态学开放研究实验室,黑龙江哈尔滨150040)      张玉红(东北林业大学森林植物生态学开放研究实验室,黑龙江哈尔滨150040)      祖元刚(东北林业大学森林植物生态学开放研究实验室,黑龙江哈尔滨150040)
基金项目:引进国外先进林业技术(林业“948”)项目( 96 -4 -10 -11),东北林业大学森林植物生态学开放实验室开放基金资助项目
摘    要:目的探讨以喜树为原料提取喜树碱的工艺条件.方法通过均匀试验设计法.结果确定了以稀NaOH溶液为溶剂提取喜树碱的最佳工艺条件提取溶剂浓度为0.3%,提取时间为3h,NaOH溶液用量1 6 mL/g原料·次.结论首次研究了以稀NaOH溶液为喜树碱提取溶剂,从很少被利用的喜树叶中提取喜树碱的工艺条件.结果表明喜树叶的喜树碱提取率达到0.1%以上,是一个较好的喜树碱提取原料.利用此方法提取喜树碱生产成本低、提取率高、防火等级低,是相对于乙醇提取更为优秀的喜树碱提取方法.

关 键 词:喜树叶 喜树碱 碱提 中药

New process for extraction of camptothecin from leaves of Camptotheca acuminata
WANG Yang,YU Tao,ZHANG Yu hong,ZU Yuan gang. New process for extraction of camptothecin from leaves of Camptotheca acuminata[J]. Researches in Medical Education, 2001, 0(10): 882-884
Authors:WANG Yang  YU Tao  ZHANG Yu hong  ZU Yuan gang
Abstract:Object To develop a new process for the extraction of camptothecin from leaves of Camptotheca acuminata Decne Methods By uniform experimental design after proper choice of solvent Results The optimal conditions were extraction with 16 times of 0 3% NaOH for three hours each time Conclusion This is the first attempt to use dilute NaOH solution for the extraction of camptothecin from the previously seldom utilized leaves of C acuminata, which resulted in a yield well over 0 1% The process resulted in a lower production cost and require less fire protection measures as compaired with the conventional use of alcohol
Keywords:leaves of Camptotheca acuminata Decne  camptothecin  extraction by dilute NaOH solution
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