| 头孢噻甲羧肟对肺炎大鼠免疫应答的调节作用 |
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| 引用本文： | 蔡少华,姚汉德,杨剑军,黄念秋,张进川,米东辉.头孢噻甲羧肟对肺炎大鼠免疫应答的调节作用[J].中国免疫学杂志,1999,0(5):209-210. |
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| 作者姓名： | 蔡少华 姚汉德 杨剑军 黄念秋 张进川 米东辉 |
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| 作者单位： | 1. 解放军总医院南楼呼吸科,北京,100853
2. 白求恩医科大学第三临床医院呼吸内科,长春130031 |
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| 摘 要： | 目的 初步探讨了头孢噻甲羧肟（ＣＡＺ）对肺炎大鼠的免疫调节作用。方法；雄性Ｗｉｓｔａｒ大鼠采用气管内注入感染法制备肺炎克雷伯氏杆菌性肺炎模型，注射治疗剂量ＣＡＺ７ｄ后测定免疫指标：结果ＣＡＺ增强巨噬细胞的吞噬功能及ＡＤＣＣ活性；降低ＣＤ４＾＋Ｔ淋巴细胞亚群，对脾小结发生中心Ｂ细胞密度，ＰＭＮ－ＣＬ及巨噬细胞ＡＣＰ活性无影响，结论：ＣＡＺ可增强肺炎大鼠巨噬细胞和抑制Ｔ淋巴细胞的免疫应答反应。
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| 关 键 词： | 头孢噻甲羧肟 大鼠 肺炎 免疫应答 调节作用 |
The effects of ceftazidime on the immune response in pneumonic rats |
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| CAI Shao Hua,YAO Han De,YANG Jian Jun et al.The effects of ceftazidime on the immune response in pneumonic rats[J].Chinese Journal of Immunology,1999,0(5):209-210. |
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| Authors: | CAI Shao Hua YAO Han De YANG Jian Jun |
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| Affiliation: | CAI Shao Hua,YAO Han De,YANG Jian Jun et al. Department of Plumonary Medicine,General Hospital of PLA,Beijing 100853 |
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| Abstract: | Objective: To study the immunomodulating effects of ceftazidime (CAZ) in pneumonic rats. Methods: The male wistar rats were infected with Pneumoniae Klebsiella species by the intratracheal peroral route. CAZ was administered at therapeutic doses intraperitoneally for 7 days and several immunologic parameters were measured. Results: CAZ increased the phagocytosis and ADCC mediated by macrophages; descreaed the number of CD4 T lymphocytes; had no significant effect on the B cell density in the germinal center of splenic follicles, PMN CL and ACP activity of the macrophages. Conclusion: CAZ could enhance or inhibite the immune response of macrophages or T lymphocytes in pneumonic rats respectively. |
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| Keywords: | Ceftazidime Rats Pneumonia |
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