中药川芎中阿魏酸稳定性的研究

目的　研究川芎中阿魏酸的稳定性 ,为其提取、浓缩及干燥等工艺参数的制定提供依据。方法　反相 HPL C法测定阿魏酸峰面积进行比较。结果　实验结果显示 ,在湿热条件下 ,阿魏酸很不稳定。当温度超过80℃时 ,阿魏酸峰面积急剧下降 ,且时间越长降低越多。但川芎药材在干燥条件下 ,其中的阿魏酸含量相当稳定。结论　在有关川芎药材的提取、浓缩及干燥过程中 ,为了获得较高的阿魏酸转移率 ,相关工艺的温度不宜超过 80℃ ,加热时间不宜超过 12 h。

Research of the Stability of Ferulic Acid in Rhizoma Chuanxiong

Objective To research the stability of ferulic acid in rhizoma ligusticum chuanxiong,to find the proper processing parameters of its extracting, concentration and drying. Methods By means of RP-HPLC, comparing the peak area of ferulic acid, so deducing the stability of ferulic acid. Results The experiments have manifested that ferulic acid was not stable when treated by heat in solution. When the temperature exceeded 80 ℃, the peak of ferulic acid dropped sharply, and this tendency was proportional with heating time, while the amount of ferulic acid in the dry crude drug of rhizoma ligusticum chuanxiong kept stable. Conclusion Based on this research, we can make the conclusion that in the relative process, such as extracting, concentration and drying, the temperature should keep under 80 ℃, and the heating time should be within 12 h, for the sake of a higher yielding of ferulic acid.