| 基于正交双偏振光的无创血糖检测方法及初步实验研究 |
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| 引用本文： | 王洪,吴宝明,刘丁. 基于正交双偏振光的无创血糖检测方法及初步实验研究[J]. 生物医学工程学杂志, 2010, 0(2) |
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| 作者姓名： | 王洪 吴宝明 刘丁 |
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| 作者单位： | 第三军医大学野战外科研究所五室创伤烧伤与复合伤国家重点实验室;重庆理工大学化学与生物工程学院;第三军医大学大坪医院检验科; |
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| 基金项目： | 重庆市科技攻关重大项目资助(7659) |
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| 摘 要： | 针对光电外差探测法和直接探测法偏振光无创血糖检测方法存在的缺点,本文提出了一种新的正交双偏振光无创血糖检测方法,将正交双偏振光通过血糖引起的微小偏振角的变化转化为两个方向上偏振光的能量差,由相关原理高灵敏锁相放大器检测,控制法拉第线圈电流补偿血糖引起的偏转角变化,利用血糖浓度与法拉第线圈电流的线性关系,计算获得血糖浓度。以LX-20全自动生化分析仪测得的数据作为标准进行对比实验,葡萄糖溶液实验的相关系数为0.9777,血清实验的相关系数为0.952。研究表明本方法具有较高的检测灵敏度和准确度,为研制实用的新型无创血糖检测仪打下了基础。
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| 关 键 词： | 血糖检测 无创检测 光学旋光 正交双偏振光 血清 |
A Non-invasive Glucose Measurement Method Based on Orthogonal Twin-polarized Light and Its Pilot Experimental Investigation |
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| Wang Hong, Wu Baoming Liu Ding. A Non-invasive Glucose Measurement Method Based on Orthogonal Twin-polarized Light and Its Pilot Experimental Investigation[J]. Journal of biomedical engineering, 2010, 0(2) |
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| Authors: | Wang Hong Wu Baoming Liu Ding |
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| Affiliation: | Wang Hong1,2 Wu Baoming1 Liu Ding31(Research Institute of Surgery & Daping Hospital of the Third Military Medical University,Chongqing 400042,China)2(College of Bioengineering,Chongqing University of Technology,Chongqing 400050,China)3(Laboratory,Daping Hospital of the Third Military Medical University,China) |
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| Abstract: | In order to overcome the existing shortcomings of the non-invasive blood glucose polarized light measurement methods of optical heterodyne detection and direct detection,we present in this paper a new orthogonal twin-polarized light(OTPL) non-invasive blood glucose measurement method,which converts the micro-angle rotated by an optical active substance such as glucose to the energy difference of OTPL,amplifies the signals by the high-sensitivity lock-in amplifier made of relevant principle,controls Faraday ... |
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| Keywords: | Glucose monitoring Noninvasive measurement Optical polarimetric sensing Orthogonal twin polarized light(OTPL) Blood serum |
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