癫痫患者认知障碍与生存质量的相关因素研究

目的 探讨癫痫患者认知功能障碍的发生率及其影响因素，并研究认知障碍时其生存质量（QOL）的影响。方法 采用瑞文标准推理测验（R’SPM）分别测评134例正常人及134例癫痫患者的认知功能，比较2组的测验得分情况，并对影响测验得分的多种因素进行相关性，最后将癫痫组按有、无认知功能障碍分为2个亚组，研究癫痫患者认知功能障碍对其QOL的影响。结果 本研究中癫痫患者认知功能障碍与起病年龄、病程、发作类型、发作频率及每次发作持续时间等密切相关；癫痫患者QOL与认知功能状况密切相关。结论 本研究中，约35％的癫痫患者有认知功能障碍，起病年龄、病程、发作类型、发作频率及每次发作持续时间对其影响较大，且认知功能与生存质量密切相关。临床应重视癫痫患者的认知功能状况，尽量减少或避免导致认知功能受损的危险因素发生，以提高癫痫患者的QOL．

Study on the Correlation Between the Cognitive Dysfunction and Quality of Life in Patients with Epilepsy

Objective To investigate the cognitive function of epileptic patients and the related factors, and to correlate them with the quality of life (QOL) of these patients. Methods The cognitive function of 134 epileptic patients and 134 healthy controls was evaluated by means of Raven's Standard Progressive Matrices (R'SPM), and comparisons between them were made. Correlation between the cognitive dysfunction and its related factors was analyzed. Finally, the epileptic group was further divided into two subgroups based on existence or not of cognitive deficit, and the QOL of two subgroups was compared. Results The total incidence of cognitive deficit in epileptic patients was 35%, which was significantly different from the control group. Among the factors related to the cognitive function of epileptic patients were the onset age of illness, duration of the disease, frequency of seizures attack before medication, type of seizures and the duration of seizures. Significant correlation was revealed between the cognitive deficit and the QOL. Conclusions About 35% of the epileptic patients have cognitive deficit. The factors contributing to the cognitive function of epileptic patients include the age of onset of illness, duration of the disease, frequency of seizures attack before medication, type of seizures, and the duration of seizures. Cognitive deficit exerts significant impact on the QOL of the epileptic patients. In order to improve the QOL, we should pay attention to the cognitive function of epileptic patients and eliminate the risk factors related to cognitive dysfunction.