缺血性脑卒中患者血纤溶活性变化规律的研究

目的 研究脑梗死组和非脑梗死组患者急性期,亚急性期和恢复期组织型纤溶酶原激活物（tPA）,纤溶酶原激活物抑制物-1（PAI-1）的变化规律.方法 135例脑梗死组患者于发病96h内,病后14d、3月、6月、9月分别采血,77例非脑梗死组患者先采血一次,然后分别在第一次采血后14d、3月、6月、9月采血.结果 脑梗死急性期tPA含量明显升高,PAI-1的含量明显升高.恢复期脑梗死即发病后3月,6月,9月tPA的含量比急性期明显降低,且脑梗死后时间越长tPA含量越低,恢复期脑梗死PAI-1的含量比急性期明显降低.结论 在缺血性卒中的患者,高tPA含量提示纤溶活性的降低.高PAI-1代表纤溶抑制增强.

The Study on Tissue Plasminogen Activator Change in Stroke Patients

Objective Since the possible variation of tissue plasminogen activator(tPA) and plasminogen activator inhibitor-1(PAI-1) concentrations over time after stroke has been rarely studied,it was examined in plasma from stroke patients in the acute,convalescent and recovery phases of the disease and in a control group.Methods Plasma concentrations of tPA and PAI-1 were determined in 135 stroke patients and in 77 control subjects.All were reexamined after 14days,3,6,9months respectively.Results In the acute phase,stroke patients had significantly higher tPA and PAI-1 concentrations,both tPA and PAI-1 levels had changed to the baseline when time passed.Conclusions In stroke patients,high tPA concentrations may indicate the decreasing of the fibrinolytic system.High PAI-1 concentrations in patients with cerebral infarction represent increased fibrinolitic inhibition.