表皮生长因子受体和Ki-67抗原在脑室管膜瘤患者肿瘤组织中的表达

目的 探讨表皮生长因子受体(EGFR)和Ki-67抗原在脑室管膜瘤中的表达及二者的相关性.方法 利用免疫组织化学方法检测40例不同级别脑室管膜瘤患者肿瘤组织中EGFR和Ki-67抗原的表达情况以及与肿瘤增值活性的相关性.结果 EGFR表达阳性率在I～Ⅱ级和Ⅲ～Ⅳ级中分别为25%和75%,差异有统计学意义(P<0.05);Ki-67抗原标记指数(LI)在脑室管膜瘤Ⅱ～Ⅱ级为(2.3±1.4)%,Ⅲ～Ⅳ级为(9.5±5.6)%,二者比较P<0.05.结论 EGFR表达阳性率随肿瘤恶性程度增加而升高;EGFR表达阳性率复发组高于原发组;Ki-67抗原和EGFR在不同级别脑室管膜瘤中表达具有正性相关性.

Expression of epidermal growth factor receptor and Ki-67 antigen in brain ependymoma and the correlation between them

Objective To study the expression of epidermal growth factor receptor (EGFR) and Ki67 antigen in human brain ependymoma and the correlation between them.Methods Immunohistocbemistry was used to detect the expression of EGFR and Ki-67 antigen in 40 specimens of brain ependymoma, 8 specimens of normal brain tissues, and 8 specimens of glioblastoma, all obtained during operation.Results The EGFR positive rate of the Ⅲ - Ⅳ grade ependymoma tissues was 75%, significantly higher than that of the grade Ⅰ - Ⅱ grade ependymoma tissues (25%, P < 0.05 ).The specimens of glioblastoma were all EGFR positive.The EGFR positive rate of the recurrent ependymoma tissues (5/6) was significantly higher than that of the primary ependymoma tissues (9/34, P < 0.05 ).The positive rate of Ki-67 L1 in the Ⅲ - Ⅳ grade epondymoma tissues was (9.5 ± 5.6) %, significantly higher than that in the grade Ⅰ - Ⅱ grade ependymoma tissues [(2.2 ± 1.4)%,P <0.05) ].The positive rate of Ki-67 L1 in the glioblastoma tissues was (9.8 ± 6.3 )%.The positivity of EGFR was positively correlated with the grade level of ependymoma and Ki-67 L1 positivity(both P < 0.01 ).Conclusion EGFR expression positive rate increases with tumor grading The positive rate of recurrent ependymoma is higher than that of the primary ependymoma.The expression of Ki-67 antigen is positively correlated with the expression of EGFR in difference grades.