中性粒细胞CD64指数测定在肺部感染性疾病诊断中的价值

目的探讨中性粒细胞CD64指数测定在肺部感染性疾病诊断和判断抗感染疗效中的价值。方法对细菌性肺炎患者30例（其中29例经抗菌药物治疗后x线摄片和临床症状显示好转，为治疗后组）、支原体肺炎患者22例以及健康对照组30名用流式细胞仪进行中性粒细胞CD64指数测定，并行血常规、红细胞沉降率（ESR）、C反应蛋白（CRP）测定。结果细菌性肺炎组CD64指数和CRP与健康对照组和支原体肺炎组比较，差异有统计学意义（P〈0．01），与治疗后组比较差异有统计学意义（P〈0．05）。CD64指数与CRP呈正相关（r=0．728，P=0．001）。CD64指数诊断细菌性怖炎的敏感性为84％、特异性为91％，CRP敏感性为89％、特异性为78％。结论CD64指数测定有助于肺部细菌感染早期诊断、鉴别诊断以及对抗感染疗效的考核.

Value of the determination of neutrophil CD64 index in the diagnosis of pulmonary infectious diseases

Objective To explore the clinical significance of the determination of neutrophil surface CD64 in the early diagnosis of pulmonary infectious diseases and its anti-infection effect. Methods The experimental group included 30 patients with bacterial pneumonia, 22 patients with mycoplasma pneumonia and 30 healthy subjects as controls. In the 30 patients with bacterial pneumonia, there were 29 patients as after-treatment group, whose situations of X-Ray film and clinical symptom were improved after antibacterial treatment. Their levels of CD64 were detected by flow cytometry. The blood routine examination, the erythrocyte sedimentation rate(ESR) and the dynamic change of the C reactive protein (CRP) were also determined. Results The CD64 index and the CRP value in the bacterial pneumonia group had a statistical difference comparing with the mycoplasma pneumonia group, the healthy control group (P<0.01) and the after-treatment group (P<0.05). The CD64 index and the CRP value had a positive correlation (r=0.728, P=0.001). The sensitivity and specificity of CD64 index were 84% and 91% respectively, while the sensitivity and specificity of CRP value were 89% and 78% respectively. Conclusions The determination of CD64 index may assist in the early diagnosis of pulmonary bacterial infection and the observation of anti-infection effect for pulmonary infection patients.