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| 健胃汤对大鼠胃溃疡愈合质量及表皮生长因子受体表达的影响 | |
| 引用本文： | 谭永港,刘志承,张永锋,杨敏. 健胃汤对大鼠胃溃疡愈合质量及表皮生长因子受体表达的影响[J]. 中国基层医药, 2006, 13(2): 187-189 |
| 作者姓名： | 谭永港 刘志承 张永锋 杨敏 |
| 作者单位： | 1. 518035,广东省深圳,深圳市第二人民医院消化内科 2. 广东省深圳市中医院药剂科 3. 广东省深圳市中西医结合临床研究所 |
| 摘 要： | 目的探讨健胃汤对溃疡愈合质量的影响及作用机制。方法采用大鼠乙酸胃溃疡模型，观察健胃汤对该模型溃疡愈合质量的影响，并用原位分子杂交法检测表皮生长因子受体mRNA（EGFR mRNA）的表达。结果健胃汤能改善胃黏膜组织损伤并提高溃疡周围组织EGFR mRNA的表达，与模型对照组比较，差异有显著意义（P〈0．05）。结论健胃汤能提高溃疡愈合质量，增强溃疡瘢痕处EGF mRNA的表达可能是其作用机制之一。 |
| 关 键 词： | 胃溃疡 健胃汤 受体 表皮生长因子 疾病模型 动物 大鼠 |
| 收稿时间： | 2005-12-08 |
| 修稿时间： | 2005-12-08 |
Effect of Jian-wei decoction on the quality of ulcer healing and expression of EGFRmRNA in the rat model of gastric ulcer |
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| TAN Yong-gang,LIU Zhi-cheng,ZHANG Yong-feng,YANG Min. Effect of Jian-wei decoction on the quality of ulcer healing and expression of EGFRmRNA in the rat model of gastric ulcer[J]. Chinese Journal of Primary Medicine and Pharmacy, 2006, 13(2): 187-189 | |
| Authors: | TAN Yong-gang LIU Zhi-cheng ZHANG Yong-feng YANG Min |
| Affiliation: | Department of Gastroenterology, Shenzhen Second People Hospital, Shenzhen , Guangdong , 518035, China |
| Abstract: | Objective To investigate the the effect and mechanism of Jian-wei decoction(JWD) on quality of ulcer healing.Methods The rat models of chronic gastric ulcer were induced by acetic acid,the effects of QOUH of JWD on the model of gastric ulcer were observed,the expression of EGFRmRNA of mucosa were measured in situ hybridization.Results JWD could improve the injury of gastric mucosa and increase the expression of EGFRmRNA in the tissue around peptic ulcer(PU).Conclusion JWD increases the expression of EGFRmRNA in the tissue around PU which might be one of possible mechanisms that JWD improves quality of ulcer healing. |
| Keywords: | Gastric ulcer Jian-wei decoction Receptor,epidermal growth factor Disease models,animal Rat |
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