血清脂蛋白(a)与缺血性脑卒中

采用 1∶1配比病例对照研究方法 ,对 10 5对缺血性脑卒中病人和非脑卒中的对照组病人 ,进行了血清脂蛋白 (a)、总胆固醇、甘油三脂、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的检测和分析 ,以评价它们与缺血性脑卒中的关系。结果显示 :病例组血清脂蛋白 (a)平均值为2 38.37mg/L ,明显高于对照组的 149.98mg/L ,t=3.97,P <0 .0 0 1,不同年龄组的比较中 ,只有 70岁以上年龄组血清脂蛋白 (a)明显高于 50岁以下年龄组 ,而性别在病例组内或对照组内均无显著性差异 ,将血清脂蛋白 (a)按不同等级进行分析 ,发现随着血清脂蛋白 (a)水平升高 ,缺血性脑卒中的危险性逐渐增加 ,有明显的剂量效应关系 ,多因素logistic回归分析表明 ,血清脂蛋白 (a)为缺血性脑卒中的独立危险因素 ,OR =1.93,其他危险因素还包括甘油三脂 ,而高密度脂蛋白胆固醇是缺血性脑卒中的保护因素 ,OR =0 .32。

A Study on the Relationship between Lp(a)and Arteriosclerotic Cerebral Infarction

Using a 1:1 matched case control study, we analysed the data of 105 arteriosclerotic cerebral infarction cases and controls to detect the levels of TC, TG, HDL-C, LDL-C and Lp(a). The results showed that the average level of Lp(a) in cases was (238.38 mg/L), significantly higher than that of controls (149.98 mg/L t = 3.96, P < 0.001). Comparing the levels of different age groups and sex, no significant difference, except the group over 70 years, which was higher than that in other groups was found. Dose-response analysis also showed that the OR value was positively correlated with the Lp(a). Multi-variable logistic regression model indicated that Lp(a) was an independent risk factor with OR = 1.93. Another risk factor was TG. However, LDL-C, HDL-C were found to be the protective factors of arteriosclerotic cerebral infarction, with an OR = 0.32.