未足月胎膜早破患者阴道菌群微生态的评价

目的对未足月胎膜早破(preterm premature rupture of membranes,PPROM)患者阴道微生态环境进行全面评价,探讨其临床意义。方法选取22~37周的PPROM孕妇100例,同时选取同期正常孕妇70例为对照组,采集阴道分泌物,对阴道菌群进行全面评价。结果 PPROM孕妇阴道分泌物过氧化氢(H2O2)的阳性率低于对照组;细菌性阴道病(bacterial vaginosis,BV)、外阴阴道假丝酵母菌病(vulvovaginal candidiasis,VVC)的患病率,无症状及体征的微生态失调状态发生率均高于对照组(P0.05)。结论 PPROM孕妇与正常孕妇阴道菌群微生态不同,推测菌群失调可能为未足月胎膜早破发生的机制。

Microecological evaluation of vaginal microflora in pregnant women with preterm premature rupture of membranes

Objective To evaluate vaginal microecology of pregnant women with preterm premature repture of membranes（PPROM） and discuss the clinical significance of microecological evaluation. Methods 100 pregnant women with PPROM in 22 37weeks were seleted as patient group and 70 normal pregnant women were selected as control group. The vaginal secretion of all cases were collected for microecological evaluation. Results The positive rate of HzO2 of vaginal secretion in pregnant women with PPROM was lower than normal pregnant women, the difference was statistically significant （P 〈0. 05 ）. The incidence of BV ,VVC and microflora abnormity increased in pregnant women with PPROM compared to that in normal pregnant women, the difference was statistically significant （P 〈 0. 05）. Conclusion Tile microecology of vaginal microflora in pregnant women with PPROM is different from that in normal pregnant women. It is assumed that the vaginal microecological disorder is likely to be the mechanism of PPROM.