| 国产与进口氯吡格雷在冠状动脉介入治疗中的疗效对比分析 |
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| 引用本文： | 阴赪茜,李志忠,张京梅,陶英,王苏,孙涛,阙斌,赵战勇,刘巍.国产与进口氯吡格雷在冠状动脉介入治疗中的疗效对比分析[J].中国新药杂志,2010(10). |
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| 作者姓名： | 阴赪茜 李志忠 张京梅 陶英 王苏 孙涛 阙斌 赵战勇 刘巍 |
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| 作者单位： | 首都医科大学附属北京安贞医院急救中心; |
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| 摘 要： | 目的:对比观察国产氯吡格雷(泰嘉)和进口氯吡格雷(波立维)对经皮冠状动脉介入治疗(PCI)术后的疗效及安全性。方法:将1 258例冠心病患者分为两组,其中国产氯吡格雷组563例,进口氯吡格雷组695例。两组患者术前1 d分别服用泰嘉或波立维300 mg,阿司匹林300 mg作为负荷量,以后泰嘉或波立维75 mg.d-1及阿司匹林100 mg.d-1两联抗血小板治疗,比较泰嘉和波立维对冠心病患者PCI术后9个月的MACE事件、血小板聚集率的影响,以及两药在PCI术后抗血小板作用的安全性。结果:国产和进口氯吡格雷组的血小板聚集率及冠心病患者PCI术后MACE事件差异无统计学意义。结论:国产和进口氯吡格雷均有良好的抗血小板作用,临床疗效相似,不良反应轻微。
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| 关 键 词： | 冠状动脉疾病 血小板聚集抑制剂 冠状动脉介入治疗 |
Efficacy and safety of domestic and imported clopidogrel after coronary stent placement in patients following percutaneus coronary intervention |
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| YIN Cheng-qian,LI Zhi-zhong,ZHANG Jing-mei,TAO Ying,WANG Su,SUN Tao,QUE Bin,ZHAO Zhan-yong,LIU Wei.Efficacy and safety of domestic and imported clopidogrel after coronary stent placement in patients following percutaneus coronary intervention[J].Chinese Journal of New Drugs,2010(10). |
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| Authors: | YIN Cheng-qian LI Zhi-zhong ZHANG Jing-mei TAO Ying WANG Su SUN Tao QUE Bin ZHAO Zhan-yong LIU Wei |
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| Institution: | YIN Cheng-qian,LI Zhi-zhong,ZHANG Jing-mei,TAO Ying,WANG Su,SUN Tao,QUE Bin,ZHAO Zhan-yong,LIU Wei(Emergengcy Center,Beijing An\'zhen Hospital,Capital University of Medical Sciences,Beijing 100029,China) |
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| Abstract: | Objective:To observe the efficacy and safety of domestic clopidogrel(Talcom) and imported clopidogrel(Plavix) in patients after elective percutaneus coronary intervention(PCI).Methods:A total of 1 258 coronary heart disease(CHD) patients were divided into Talcom group(n=563) and Plavix group(n=695).Clopidogrel 300mg and asprin 300mg were taken as a loading dose in all CHD patients 1 day before PCI,fellowed by clopidogrel 75mg and asprin 100mg daily for 1 year.The death rate,recurrent angina pectoris,instent... |
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| Keywords: | coronary disease platelet aggregation inhibitors percutaneous coronary intervention(PCI) |
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