中年抑郁症患者颈动脉粥样硬化风险的研究

【目的】研究探讨中年抑郁症患者发生颈动脉粥样硬化的风险。【方法】以本院门诊收治的78例首诊抑郁症患者及85例健康对照患者为研究对象，测量颈动脉内膜中层厚度（IMT），记录吸烟史、糖尿病史及高血压病史，测量体重指数（BMD、空腹血糖、低密度脂蛋白胆固醇（LDL—C）水平，比较两组患者IMT平均值的差异及抑郁对IMT的影响。【结果】抑郁组IMT平均值为0．852mm，高于对照组0．753mm（P=0．027）；抑郁组颈动脉粥样硬化（IMT≥0．9mm）37例，占47．74％，高于对照组26例（30．59％），OR值=2．048，95％CI为1．079～3．886（P=0．036），Logistic回归分析显示提示吸烟、糖尿病、LDL-C及抑郁可能为颈动脉粥样硬化的独立危险因素。【结论】中年抑郁症患者患颈动脉粥样硬化的风险升高，积极防治抑郁并筛查颈动脉超声可能有助于预防颈动脉粥样硬化、甚至中年脑梗死的发生。

Study on the Risk of Carotid Atherosclerosis in Middle-aged Patients with Depression

Objective]To investigate the risk of carotid atherosclerosis in middle-aged patients with depression. Methods]The carotid artery intima medial thickness（IMT） of 78 outpatients with depression and 85 healthy controls were detected. Low density lipoprotein cholesterin（LDL-C） and body mass index（BMI） were also examined. The history of smoking, hypertension and diabetes mellitus（DM） was＇recorded. IMT between the two groups was compared and the influence of depression on IMT was analyzed. Results] Mean IMT was higher in depression group than that in control group（0. 852mm vs 0. 753mm, P =0. 027）. The incidence of IMT above 0.9ram in depression group was higher than that in control group（47. 74% vs 30. 59%, OR= 2. 048, 95 %CI= 1. 079 - 3. 886, P = 0. 036）. And logistic regression analysis revealed that smoking, DM, LDL-C and depression were independent risk factors for carotid atheroscterosis. Conclusion]Middle-aged patients with depression are more susceptive to carotid atherosclerosis than those without depression. Anti-depression treatment and carotid artery ultrasonography may prevent carotid atherosclerosis and ischemic stroke in middle-aged patients with depression. 7