天津地区丙型肝炎病毒基因型与临床的相关性研究

目的：研究丙型肝炎病毒（HCV）基因型，了解天津地区丙型肝炎的分布情况。方法：收集252例丙型肝炎患者的血清标本，采用基因测序法进行HCV基因型的检测，并对基因型与其他临床指标进行分析。结果：252例丙型肝炎患者分别感染1b、1a、1c、2a、2i、3a、3b、4a和6a共9种基因亚型，其中1b型占59．9％，其次是3a型，占12．7％。对1型、2型、3型和4型4种基因型进行肝功能、HCVRNA病毒载量比较，经单因素方差分析有明显统计学差异（P〈0．05）；对HCV感染的不同肝病程度患者的基因型分布进行分析，无显著性差异（P〉0．05）。结论：天津地区丙型肝炎病毒感染以1b型为主，其次为3a型。HCV基因型与HCVRNA病毒载量、肝脏损伤指标有明显统计学差异。

Correlation between hepatitis C virus genotypes and clinical index in Tianjin

Objective： To study the hepatitis C virus（HCV） genotype in chronic hepatitis C patients and explore the distribution of hepatitis C in Tianjin region. Methods： Serum specimens from 252 patients hepatitis C were collected for genotype by gene sequencing technique. Results：In the 252 specimens with HCV infection, nine gene genotypes were detected, including 1 b （59.9%）, 1 a, 1 c, 2a, 2i, 3a （ 12.7% ）, 3b, 4a and 6a. Significant difference was observed between HCV genotypes and HCV RNA,liver function （P〈0.05）. No significant difference between HCV genotypes and various liver diseases distribution was found （P〉0.05）. Conclusion： HCV lb is the most prevalent type in Tianjin, followed by type 3a. HCV genotypes are associated with HCV RNA level and liver function.