抗糖尿病先导化合物Fla—CN的合成工艺研究

目的：对抗糖尿病先导化合物Fla—CN（3-O-[（E）-4-（4-氰基苯基）-3-烯-2-酮丁基]山萘酚）的合成工艺进行研究。方法：以对氰基苯甲醛和山萘酚为合成起始原料，先后经过Claisen—Schimidt反应，a，β-不饱和酮的a位溴代反应和醚化反应得到目标化合物Fla—CN．并从反应温度、底物浓度、反应物当量比以及催化剂等方面进行单因素考察试验，摸索最佳反应条件，建立合成工艺，提高反应总收率。结果：通过单因素考察等方法，建立了Fla—CN的合成工艺，目标产物的总收率显著提高，达到50％。结论：该工艺采用价廉易得的原料．简便的合成工艺与纯化手段，提高了反应收率，降低了生产成本。

Study on the synthesis process of anti-diabetic lead compound FIa-CN

Objective： To explore the synthesis process of anti-diabetic lead compound Fla-CN （3-O-[（E）-4-（4-Cyanophenyl）-2-oxobut- 3-en-1-yl] kaempferol）. Methods： The target compound Fla-CN was prepared from 4-eyano benzaldehyde and kaempferol via Claisen- Schimidt condensation, a-bromination of the a, β-unsaturated ketone, and etherification reaction. To establish a suitable synthesis process for a high yield. The preferred reaction conditions including reaction temperature, substrate concentration, reactants proportion and the catalyst were explored by single-factor experiments. Results： The synthesis process of Fla-CN was established by single-factor experiments. The total yield hacl significantly increased to 50%. Conclusion： The preferred synthesis process could increase the total yield and reduce costs using cheap raw materials, convenient preparation and purification methods.