颈动脉内中膜厚度与H型高血压及相关因素的分析

目的：探讨颈动脉内中膜厚度与H型高血压及相关因素的关系.方法：选取244例高血压患者,根据同型半胱氨酸（Hcy）水平分为H型高血压组（Hcy≥10 μmol/L）、非H型高血压组（Hcy＜10μmol/L）,测量颈动脉内中膜厚度（IMT）,观察有无斑块、斑块位置及类型,计算斑块积分并测量血甘油三酯（TG）、胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）等指标;同时收集年龄、性别、病程等流行病学资料.结果：H型高血压组颈动脉IMT、斑块积分、斑块检出率、合并脑梗死及冠心病构成比均高于非H型高血压组,两组间差异有统计学意义（P＜0.05）.相关分析显示：颈动脉IMT与Hcy、空腹血糖（FBG）、HDL-C、年龄及高血压病程有相关性.结论：H型高血压与颈动脉内中膜厚度密切相关,高同型半胱氨酸可在高血压的基础上加速动脉硬化的进程.

Analysis on carotid intima-media thickness,H type of hypertension and related factors

Objective： To investigate the relationship of carotid intima-media thickness （IMT） and H-type hypertension as well as its relevant factors. Methods： According to their levels of Hcy, 244 patients were divided into two groups： the H-type hypertension group （Hcy ≥ 10 μmo/L） and non-H-type hypertension group （Hcy〈 10 p~mol/L）. Carotid intima-media thickness was measured and the location and type of plaque were observed. Meanwhile, the plaque integral was calculated and the blood triglycerides, cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and other indicators were all measured epidemiological data such as age, gender, duration were collected. Results： In the H-type hypertension group, the factor values of IMT, plaque score, plaque detection rate, merging, cerebral infarction and coronary heart disease were higher than those in non-H-tyne hypertension group （P〈0.05）. Analysis showed that IMT was correlated with Hcy and FBG, HDL-C, age as well as hypertension duration. Conclusion： The high incidence of H- type hypertension is related to IMT. High homocysteine can accelerate the process of arteriosclerosis in the condition of hypertension.