| 环氧化酶-2在脑膜瘤中的表达及意义 |
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| 引用本文： | 李新军,徐宏,夏祥国. 环氧化酶-2在脑膜瘤中的表达及意义[J]. 中华神经外科疾病研究杂志, 2008, 7(5): 388-390 |
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| 作者姓名： | 李新军 徐宏 夏祥国 |
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| 作者单位： | 德阳市人民医院脑外科,四川,德阳,618000 |
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| 摘 要： | 目的通过检测环氧化酶-2（COX-2）在人脑膜瘤、正常脑膜组织中的表达，探讨COX-2在人脑膜瘤发生、发展过程中的作用。方法采用免疫组织化学方法检测人脑膜瘤、正常脑膜组织中COX-2的表达及其与脑膜瘤的病理分级、侵袭性、瘤周水肿等临床病理因素的关系。结果47例脑膜瘤组织中，36例有COX-2表达，阳性表达率为76．6％，正常脑膜无COX-2表达。COX-2在患者的年龄（P〉0．05）、性别（P〉0．05）之间的表达差异无统计学意义，而在肿瘤病理分级（P〈0.01）、侵袭性（P〈0．05）、瘤周水肿（P〈0．05）之间的表达差异有统计学意义。结论COX-2在脑膜瘤中普遍表达，其与脑膜瘤的病理分级、侵袭性、瘤周水肿等临床病理因素密切相关，COX-2可能在人脑膜瘤的发生发展中起重要作用。
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| 关 键 词： | 脑膜瘤 环氧化酶-2 增殖细胞核抗原 |
The expressiin and sugnificance of cyclooxygenase-2''(COX-2)in meningiomas |
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| LI Xinjun,XU Hong,XIA Xiangguo. The expressiin and sugnificance of cyclooxygenase-2''(COX-2)in meningiomas[J]. Chinese Journal of Neurosurgical Disease Research, 2008, 7(5): 388-390 |
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| Authors: | LI Xinjun XU Hong XIA Xiangguo |
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| Affiliation: | ( Department of Neurosurgery,The People＇s Hospital of Deyang, Deyang 618(EO,China) |
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| Abstract: | Objective To detect the expression of cyclooxygenase-2(COX-2) in the human meningiomas and discuss the effect of COX-2 in the formation and development of meningiomas.Methods The expression of COX-2 in 47 samples of meningioma tissues and 10 samples of normal cerebral dura maters was detected by immunohistochemistry.Results Of 47 cases of meningiomas,36 cases(76.6%) showed positive COX-2 immunoreactivity.The common cerebral maters were immunonegative for COX-2.COX-2 expression exhibited no statistical significance in age(P>0.05) and sex(P>0.05),but it presented statistical significance in pathologic grades(P<0.01),invasion(P<0.05) and peritumoral edema(P<0.05).Conclusion COX-2 is overexpressed in human meningiomas.The expression of COX-2 in meningiomas correlates significantly to the tumors' clinicopathology.It may play an important role in the genesis and development of meningiomas. |
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| Keywords: | Meningioma Cyclooxygenase-2 Proliferating cell nuclear antigen |
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