抗精神病药物在维持治疗中对心电图影响的分析 |
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引用本文: | 孔令芳,盛嘉玲,顾燕,吕珍苏,张忆军,刘焱. 抗精神病药物在维持治疗中对心电图影响的分析[J]. 中国民康医学, 2012, 24(23): 2853-2855 |
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作者姓名: | 孔令芳 盛嘉玲 顾燕 吕珍苏 张忆军 刘焱 |
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作者单位: | 上海市民政第一精神卫生中心 |
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摘 要: | 目的:探讨抗精神病药物在慢性精神病患者维持治疗中对心电图的影响。方法:用自编的《住院精神病患者心电图异常调查表》对本院长期住院患者进行调查,对入组患者行十二导联心电图检查。根据检测结果对心电图异常发生率,服用和未服用抗精神病药物,药物的种类、剂量等因素进行统计分析。结果:本组患者599人中,其中心电异常人数229人,占38.23%。服用抗精神病药物者469人,有心电异常者187(占31.22%);未服抗精神病药物者130人,有心电异常者42人(占7.01%),两者差异有显著性(P值〈0.05)。心电异常发生率最高的为:传导阻滞、窦性心动过速、T波改变。药物种类中以氯氮平组发生心电异常率最高70例(占40.70%),氯丙嗪组次之为86例(占39.27%),奋乃静组14例(占32.56%),利培酮组17例(占30.36%)。抗精神病药物剂量的大小与心电图异常间的差异无统计学意义(P值〉0.05)。结论:抗精神病药物在精神病维持治疗中对心电图的影响是很常见的,与剂量的大小无关,利培酮和奋乃静对心电图影响小于氯氮平、氯丙嗪。
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关 键 词: | 抗精神病药物 维持治疗 心电图异常 慢性精神病患者 |
Electrocardiogram changes in psychiatric patients treated with antipsychotics |
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Affiliation: | KONG Ling-fang,SHENG Jia-ling,GU Yan,et al(Shanghai No.1 Mental Health Center of Civil Administration,Shanghai 201105,China) |
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Abstract: | Objective:To investigate the effects of antipsychotics on electrocardiogram ( ECG ) changes in psychiatric pa- tients. Methods : The ECG of patients with antipsychotics were collected and the kinds of antipsychotics were compared. Results: A to- tal of 599 patients were evaluated. There were 229( 38.23% ) patients with abnormal ECG, and conduction block was the most com- mon abnormal change, followed by tachycardia and T - wave changes. The abnormal ECG rates of clozapine, chloropromazine, chlor- perphenazine and risperidone were 40.70%, 39.27%, 32.56% and 30.36% , respectively. For all agents, there was no dose - re- sponse relationship for ECG changes. Conclusions: The ECG changes are common in patients with antipsychotics. The abnormal rate was lower in patients with risperidone and chlorperphenazine than others. |
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Keywords: | Antipsychotics Treated ECG Psychiatric patients |
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