| 京尼平苷对类风湿性关节炎大鼠血清IL-1β和TNF-α的影响 |
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| 引用本文： | 朱江高欣,谢文利,晋玉章,孙文军.京尼平苷对类风湿性关节炎大鼠血清IL-1β和TNF-α的影响[J].中国中药杂志,2005,30(9):708-711. |
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| 作者姓名： | 朱江高欣 谢文利 晋玉章 孙文军 |
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| 作者单位： | 武警医学院,天津,300162 |
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| 摘 要： | 目的:研究京尼平苷对类风湿性关节炎大鼠血清IL1β和TNFα的影响,进一步探讨该药物的作用机制。方法:建立Ⅱ型胶原蛋白诱导大鼠类风湿性关节炎模型。观察京尼平苷对实验性大鼠足肿胀的抑制作用;检测血清IL1β和TNFα的水平。结果:与模型组比较,京尼平苷可以延缓对侧肢体足肿胀发生的时间,抑制大鼠足肿胀的程度(P<0.01);用药后,中、高剂量给药组血清IL1β和TNFα水平明显低于模型组(P<0.01)。结论:京尼平苷在类风湿性关节炎大鼠中可以下调致炎因子IL1β和TNFα的水平,提示这可能与该药抑制实验性类风湿性关节炎病情进展密切相关。
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| 关 键 词： | 京尼平苷 类风湿性关节炎 白细胞介素1 肿瘤坏死因子 |
| 文章编号： | 1001-5302(2005)09-0708-04 |
| 收稿时间： | 7/8/2004 12:00:00 AM |
Effect of geniposide on serum IL-1β and TNF-α of rheumatoid arthritis rats |
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| ZHU Jiang;GAO Xin;XIE Wen-li;JIN Yu-zhang;SUN Wen-jun.Effect of geniposide on serum IL-1β and TNF-α of rheumatoid arthritis rats[J].China Journal of Chinese Materia Medica,2005,30(9):708-711. |
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| Authors: | ZHU Jiang;GAO Xin;XIE Wen-li;JIN Yu-zhang;SUN Wen-jun |
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| Institution: | Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China. |
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| Abstract: | OBJECTIVE: To study the effect of geniposide on serum IL-1beta and TNF-alpha levels of rheumatoid arthritis rats, as well as the mechanism of this drug. METHOD: To establish an experimental rat model of type II collagen-induced arthritic (CIA). The inhibitory effects on paw edema were observed, and serum IL-1beta and TNF-alpha levels were determined in experimental rats. RESULT: Compared with the model, geniposide delayed the starting time of right paw edema significantly, and the levels of serum IL-1beta and TNF-alpha were significantly decreased by geniposide at high dose or medium dose (P < 0.01). CONCLUSION: Geniposide can lower serum IL-1beta and TNF-alpha levels in rheumatoid arthritis rats. The effect may be close related to inhibitory development of rheumatoid arthritis by the agent. |
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