山东省东平县食管癌危险因素交互作用研究

目的 探讨食管癌致病因子以及致病因子之间的交互作用。方法 对2004年1月1日—2005年12月31日山东省东平县472例新发食管癌患者和472名均衡性较好的对照者进行对比研究。在非条件Logistic回归分析的基础上,分析东平县食管癌各致病因子病因分值及食管癌家族史与其他各致病因子的交互作用。结果 人群病因分值由大到小依次为喜烫食（0.855）、喜食腌制品（0.758）、喜食干硬食物（0.683）、好生闷气（0.464）、饮用水污染（0.459）、食管癌家族史（0.343）、大量饮酒（0.108）。预防分值由大到小依次为大量饮酒（-0.121）、食管癌家族史（-0.520）、饮用水污染（-0.850）、好生闷气（-0.864）、喜食干硬事物（-2.160）、喜食腌制品（-3.133）、喜烫食（-5.907）。在食管癌家族史与其他某一危险因素同时存在并协同作用中,以食管癌家族史＋烫食、食管癌家族史＋喜食干硬食物最为显著,其交互作用指数均为0.86,均有统计学意义。结论 食管癌家族史与不良生活行为方式的交互作用在食管癌发生过程中尤为重要。

Interaction of Risk Factors for Esophageal Cancer in Dongping County

Objective To explore the risk factors of esophageal cancer and these factors＇ interaction Methods 472 new diagnosed cases of esophageal cancer in 2004-2005 and 472 controls were investigated by case-control study. Etiological fractions and interactions between family history of esophageal cancer and other risk factors of esophageal cancer were analyzed. Results The significant independent risk factors included taking hot-meal, preferring pickled-vegetables, preferring dry-rigidity-food, being irrita- ble, drinking polluted-water perennially, family history of esophageal cancer and drinking alcohol a great deal. The etiologic fractions attributable to interaction were 0.855, 0.758, 0.683, 0.464, 0.459, 0.343 and 0.108 respectively. The synergy indexes of family history of esophageal cancer with taking hot-meal and with preferring dry-rigidity-food were both 0.86. Concludes The interactions between family history of esophageal cancer and ill life-behavior-style or drinking polluted-water perennially were particularly significant in the development of esophageal cancer in Dongping County.