| P53 codon 72 polymorphism and ovarian cancer risk： a meta-analysis |
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| 引用本文： | Zhizhong Zhang,Guangbo Fu,Meilin Wang,Na Tong,Shizhi Wang,Zhengdong Zhang. P53 codon 72 polymorphism and ovarian cancer risk： a meta-analysis[J]. 南京医科大学学报(自然科学版), 2008, 28(5): 279-285 |
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| 作者姓名： | Zhizhong Zhang Guangbo Fu Meilin Wang Na Tong Shizhi Wang Zhengdong Zhang |
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| 作者单位： | Zhizhong Zhanga，b，1，Guangbo Fud，1，Meilin Wanga，b，NaTongc，Shizhi Wangb，Zhengdong Zhanga，b，c* aCancer Center，Nanjing Medical University，Nanjing 210029，Jiangsu Province，China bDepartment of Molecular and Genetic Toxicology，Nanjing Medical University，Nanjing 210029，Jiangsu Province，China cDepartment of Epidemiology and Biostatistics，Nanjing Medical University，Nanjing 210029，Jiangsu Province，China dDepartment of Urology，the Huai-An First Affiliated Hospital of Nanjing Medical University，Huai-An 223300，Jiangsu Province，China |
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| 基金项目： | 国家自然科学基金，教育部高等学校博士学科点专项科研基金，江苏省自然科学基金，中国博士后科学基金，江苏省博士后科学基金，Qinglan Project Fundation for the Young Academic Leader of Jiangsu Province |
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| 摘 要： | Objective:p53 is a tumor suppressor gene and is involved in the etiology of ovarian cancer.Studies investigating the associations between the p53 codon 72 polymorphism and ovarian cancer risk showed conflicting results.We performed this meta-analysis from eligible studies to evaluate this purported relationship.Methods:This meta-analysis was performed from 9 case-control studies, including 825 ovarian cases and 1073 controls.The fixed and random effect models were used to estimate the odds ratios(ORs)for various contrasts of this polymorphism.Results:The combined results based on all studies showed that a significantly decreased risk was associated with the variant Pro/Pro genotype,compared with Arg/Pro Arg/Arg genotypes(OR,0.70;95%CI,0.51~0.95).When stratifying the studies by ethnicity,we found that individuals with the variant genotype Pro/Pro had a significantly decreased risk of ovarian cancer compared with Arg/Arg genotype(OR,0.43;95%CI,0.20~0.89)and Arg/Pro Arg/Arg genotypes(OR,0.61;95%CI, 0.37~0.99)among Africans.Conclusion:This meta-analysis suggests that the p53 codon 72 polymorphism may contribute to genetic susceptibility to ovarian cancer.More studies based on larger sample size should be performed to confirm the findings.
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| 关 键 词： | 卵巢癌 肿瘤抑制基因 P53 遗传多样性 遗传敏感性 元分析 |
| 收稿时间： | 2008-07-19 |
P53 codon 72 polymorphism and ovarian cancer risk: a meta-analysis |
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| Zhizhong Zhang,Guangbo Fu,Meilin Wang,Na Tong,Shizhi Wang and Zhengdong Zhang. P53 codon 72 polymorphism and ovarian cancer risk: a meta-analysis[J]. Acta Universitatis Medicinalis Nanjing, 2008, 28(5): 279-285 |
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| Authors: | Zhizhong Zhang Guangbo Fu Meilin Wang Na Tong Shizhi Wang Zhengdong Zhang |
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| Affiliation: | [1]Cancer Center, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China [2]Department of Molecular and Genetic Toxicology, Nanjing Medical University, Nanfing 210029, Jiangsu Province, China [3]Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China [4]Department of Urology the Huai-An First Affiliated Hospital of Nanjing Medical University, Huai-An 223300, Jiangsu Province, China |
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| Abstract: | Objective:p53 is a tumor suppressor gene and is involved in the etiology of ovarian cancer.Studies investigating the associations between the p53 codon 72 polymorphism and ovarian cancer risk showed conflicting results.We performed this meta-analysis from eligible studies to evaluate this purported relationship.Methods:This meta-analysis was performed from 9 case-control studies, including 825 ovarian cases and 1073 controls.The fixed and random effect models were used to estimate the odds ratios(ORs)for various contrasts of this polymorphism.Results:The combined results based on all studies showed that a significantly decreased risk was associated with the variant Pro/Pro genotype,compared with Arg/Pro Arg/Arg genotypes(OR,0.70;95%CI,0.51~0.95).When stratifying the studies by ethnicity,we found that individuals with the variant genotype Pro/Pro had a significantly decreased risk of ovarian cancer compared with Arg/Arg genotype(OR,0.43;95%CI,0.20~0.89)and Arg/Pro Arg/Arg genotypes(OR,0.61;95%CI, 0.37~0.99)among Africans.Conclusion:This meta-analysis suggests that the p53 codon 72 polymorphism may contribute to genetic susceptibility to ovarian cancer.More studies based on larger sample size should be performed to confirm the findings. |
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| Keywords: | p 53 ovarian cancer genetic susceptibility meta-analysis |
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