| 大肠癌组织CD44v6的表达及其临床意义 |
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| 引用本文： | 徐钊,张霞,房殿春,晋华源,阎晓初,王东旭. 大肠癌组织CD44v6的表达及其临床意义[J]. 第三军医大学学报, 1999, 21(12): 911-913 |
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| 作者姓名： | 徐钊 张霞 房殿春 晋华源 阎晓初 王东旭 |
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| 作者单位： | 1. 第三军医大学附属西南医院消化内科,重庆,400038
2. 白求恩国际和平医院特诊科,石家庄,050082 |
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| 摘 要： | 目的：探讨血清透明质酸（ＨＡ）及大肠癌组织中ＣＤ４４ｖ６的表达对大肠癌预后的判断价值。方法：６０例大肠癌患者血清ＨＡ含量采用产免法检测，大肠癌组织ＣＤ４４ｖ６的表达采用免疫组织化学ＡＢＣ法。结果：６０例大肠癌组织中，有ＣＤ４４ｖ６检出才４５例，占７５％，Ｄｕｋｅｓ Ｃ、Ｄ期及有淋巴结转移者其ＣＤ４４ｖ６的表达明显高于Ｄｕｋｅｓ Ａ、Ｂ期及无淋巴结转移者（Ｐ〈０．０１），ＣＤ４４ｖ６的表达与患者性别
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| 关 键 词： | 大肠癌 预后 |
| 文章编号： | 1000-5404(1999)12-0911-03 |
Expression of CD44v6 in colorectal cancer and its clinical significance |
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| XU Zhao,ZHANG Xia,FANG Dian-chun,JIN Hua-yuan,YAN Xiao-chu,WANG Dong-xu. Expression of CD44v6 in colorectal cancer and its clinical significance[J]. Acta Academiae Medicinae Militaris Tertiae, 1999, 21(12): 911-913 |
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| Authors: | XU Zhao ZHANG Xia FANG Dian-chun JIN Hua-yuan YAN Xiao-chu WANG Dong-xu |
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| Abstract: | Objective: To explore the value ofhylauronicacid (HA) in serum and CD44v6 in cancerous tissue in predicting the prognosis of colorectal cancer. Methods: The concentration of HA in serum and expression of CD44v6 in the cancerous tissue in 60 cases of colorectal cancer were determ ined with radioim m unologicalassay and im m unohistochem istry respectively. Results: The expression ofCD44v6 was seen in 45 outofthe60cases.Theconcentration ofHAin serum and expression ofCD44v6 in thecancerous tissue w ere significantly higher in patientsofDukesstagesofCand Dorwith lymph nodem etastasis than in those ofDukes stages ofA and Bor withoutlym ph node m etastasis (P< 0.01). The concentration ofHA was increased along w ith the enhancem ent ofthe expression ofCD44v6. Conclusion: Concentration ofHA and expression ofCD44v6 are both im portantindexesforpredicting prognosisofcolorectalcancer. |
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| Keywords: | CD44v6 |
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