| 不同促渗剂对芍药苷透皮吸收的影响 |
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| 引用本文： | 周蕾,陈彦,张振海,吴青青,刘璇,杜萌,王晋艳. 不同促渗剂对芍药苷透皮吸收的影响[J]. 中华中医药杂志, 2011, 0(9): 2100-2103 |
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| 作者姓名： | 周蕾 陈彦 张振海 吴青青 刘璇 杜萌 王晋艳 |
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| 作者单位： | 江苏大学药学院;国家中医药管理局中药释药系统重点研究室江苏省中医药研究院中药新型给药系统重点实验室; |
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| 基金项目： | 江苏省中医药领军人才项目(No.LJ200913)~~ |
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| 摘 要： | 目的:研究6种促渗机制不同的促渗剂对芍药苷透皮吸收的影响。方法:采用改良的Franz扩散池,以生理盐水为接收介质,以小鼠离体腹部皮肤为透皮屏障,计算不同浓度促渗剂和不同种类促渗剂作用下芍药苷的累积渗透量Q及相关参数。结果:不同促渗剂对芍药苷都有不同程度的促渗作用。结论:0.2%卡波姆凝胶的促渗效果最好,本实验为芍药苷透皮吸收制剂处方的优化提供依据。
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| 关 键 词： | 芍药苷 渗透促进剂 透皮吸收 |
Effect of different penetration enhancers on percutaneous absorption of paeoniflorin |
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| ZHOU Lei,,CHEN Yan,ZHANG Zhen-hai,WU Qing-qing,LIU Xuan,DU Meng,WANG Jin-yan. Effect of different penetration enhancers on percutaneous absorption of paeoniflorin[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2011, 0(9): 2100-2103 |
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| Authors: | ZHOU Lei CHEN Yan ZHANG Zhen-hai WU Qing-qing LIU Xuan DU Meng WANG Jin-yan |
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| Affiliation: | ZHOU Lei1,2,CHEN Yan1,ZHANG Zhen-hai1,WU Qing-qing1,LIU Xuan2,DU Meng2,WANG Jin-yan1,2 (1Department of Pharmaceutics,Jiangsu University,Zhenjiang 212013,China,2Key Laboratory of New Drug Delivery System of Chinese Meteria Medica,Jiangsu Provincial Academy of Chinese Medicine,Nanjing 210028,China) |
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| Abstract: | Objective: To study the effect of 6 kinds of penetration enhancer on percutaneous absorption of paeoniflorin across mice skin.Methods: Using Franz diffusion cells,isolated mice abdomen skin as in vitro transderm albarrier and saline isotonic solution as receptor fluid,the cumulative amount of paeoniflorin permeated across mice skin perunit area and relative parameter were evaluated with the enhancers.Results: The different enhancer enhanced paeoniflorin to permeat across skin.Conclusion: 0.2% carbomer was t... |
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| Keywords: | Paeoniflorin Penetration enhancer Percutaneous absorption |
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