| 四逆散对疲劳大鼠学习记忆及脑内NMDANR1表达的影响 |
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| 引用本文： | 刘燕,宋月晗,刘晓兰,马佳美,范新六,王霁,许展嘉,李峰.四逆散对疲劳大鼠学习记忆及脑内NMDANR1表达的影响[J].中华中医药杂志,2011(10):2365-2366. |
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| 作者姓名： | 刘燕 宋月晗 刘晓兰 马佳美 范新六 王霁 许展嘉 李峰 |
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| 作者单位： | 北京中医药大学; |
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| 基金项目： | 国家自然基金项目(No.30873217)~~ |
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| 摘 要： | 目的:探讨四逆散对疲劳大鼠学习记忆及脑内NMDANR1受体的影响。方法:应用游泳训练和睡眠剥夺方法复制疲劳动物模型,运用Y-迷宫检测各组大鼠的学习记忆能力,采用免疫组化方法检测大鼠脑内NMDANR1受体阳性反应物的变化。结果:模型组与正常组相比,大鼠Y迷宫正确反应率明显下降,错误反应率明显升高,大鼠脑内NMDANR1的阳性反应物数目明显减少(P<0.01);中药治疗组与模型组相比,正确反应率明显升高,错误反应次数明显下降,脑内NMDANR1受体的阳性反应物数目明显增多(P<0.05,P<0.01)。结论:四逆散对疲劳大鼠学习记忆能力的下降具有改善作用。
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| 关 键 词： | 四逆散 学习记忆 N-甲基-D-天冬氨酸受体 |
Effects of Sinisan on learning and memory and the expression of NMDA receptor NR1 in fatigue model rats |
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| LIU Yan,SONG Yue-han,LIU Xiao-lan,MA Jia-mei,FAN Xin-liu,WANG Ji,XU Zhan-jia,LI Feng.Effects of Sinisan on learning and memory and the expression of NMDA receptor NR1 in fatigue model rats[J].China Journal of Traditional Chinese Medicine and Pharmacy,2011(10):2365-2366. |
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| Authors: | LIU Yan SONG Yue-han LIU Xiao-lan MA Jia-mei FAN Xin-liu WANG Ji XU Zhan-jia LI Feng |
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| Institution: | LIU Yan,SONG Yue-han,LIU Xiao-lan,MA Jia-mei,FAN Xin-liu,WANG Ji,XU Zhan-jia,LI Feng (Beijing University of Chinese Medicine,Beijing 100029,China) |
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| Abstract: | Objective: To investigate the effects of Sinisan on learning and memory in fatigue model and the expression of NMDA receptor NR1 in rats brain.Methods: Fatigue model were established by the method of swimming training and sleep deprivation.To evaluate learning and memory changes through Y-maze and the changes of positive cell counts of NMDA receptors NR1 in rat brain by immunohistochemical method.Results: The correct response rate of Y-maze was obviously lower in the model group than that in the normal cont... |
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| Keywords: | Sinisan Learning and memory NMDA receptor NR1 |
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