| FOLFOX4方案治疗晚期胃癌的疗效观察 |
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| 引用本文： | 余嘉文. FOLFOX4方案治疗晚期胃癌的疗效观察[J]. 安徽医学, 2011, 0(10): 1728-1730. DOI: 10.3969/j.issn.1000-0399.2011.10.027 |
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| 作者姓名： | 余嘉文 |
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| 作者单位： | 246001, 安庆石化医院肿瘤科 |
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| 摘 要： | 目的观察奥沙利铂（L-OHP）联合5氟尿嘧啶（5-Fu）、亚叶酸钙（CF）（FOLFOX4）方案治疗晚期胃癌的疗效及不良反应。方法全组27例,应用奥沙利铂85mg/m2静脉输注3 h,第1 d;亚叶酸钙200mg/m2静脉输注,第1、2 d;5-氟尿嘧啶400 mg/m2静脉推注,第1、2 d,5-氟尿嘧啶600 mg/m2静脉持续泵入22 h,第1、2 d,每2周重复,至少进行3周期。评估疗效、不良反应和总有效率,计算疾病进展时间（TTP）和总生存期（OS）。结果 27例患者总有效率50%,中位TTP 8个月（1～19个月）,中位OS 9个月（3～20个月）。最常见的不良反应是外周感觉神经异常、消化道反应和骨髓抑制。但毒副反应可控。结论 FOLFOX4方案治疗晚期胃癌疗效好,不良反应可以耐受。
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| 关 键 词： | 奥沙利铂 5-氟尿嘧啶 亚叶酸钙 晚期胃癌 化疗 |
The observation of FOLFOX4 in the treatment of advanced gastric cancer |
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| Yu Jiawen. The observation of FOLFOX4 in the treatment of advanced gastric cancer[J]. Anhui Medical Journal, 2011, 0(10): 1728-1730. DOI: 10.3969/j.issn.1000-0399.2011.10.027 |
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| Authors: | Yu Jiawen |
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| Affiliation: | Yu Jiawen Department of Oncology,Shihua Hospital,Anqing 246001,China |
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| Abstract: | Objective To evaluate the efficacy and toxicity of oxaliplatin combined with 5-fluorouracil and leucovorin(FOLFOX4) in the treatment of advanced gastric cancer.Methods 27 patients with advanced gastric cancer were treated with chemotherapy of regiment oxaliplatin 85 mg/m2 ivgtt 3h d1;LV 200mg/m2 ivgtt 2 h followed by 5-Fu 400 mg/m2(bolus)and 5-Fu 600 mg/m2(22h-continuous infusion)d1,2 and repeated every 2 weeks,All patients received three cycles of chemotherapy at least.Results The total effective rate was ... |
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| Keywords: | Oxaliplatin 5-fluorouracil Leucovorin Advanced gastric cancer Chemotherapy |
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