| 依达拉奉注射液安全性实验研究 |
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| 引用本文： | 刘良刚,宋继胜,沈怀桂,乌彪. 依达拉奉注射液安全性实验研究[J]. 安徽医学, 2011, 0(9): 1335-1337 |
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| 作者姓名： | 刘良刚 宋继胜 沈怀桂 乌彪 |
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| 作者单位： | 237000,六安 安徽省军区六安军分区离职干部修养所门诊部;230088,合肥 久诺医药科技有限公司 |
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| 摘 要： | 目的对依达拉奉注射液进行豚鼠主动全身过敏反应试验、家兔溶血试验和血管刺激性试验,为其临床应用提供安全性依据。方法豚鼠主动全身过敏反应,在第一次给药后21 d,从耳缘静脉注射依达拉奉注射液观察注射后30 m in动物的过敏症状;体外溶血试验,观察本品在3 h内有无溶血和聚集现象;血管刺激性试验,观察连续用药7 d依达拉奉注射液及生理盐水,以及恢复2 d和14 d后的注射局部血管和周围组织反应情况。结果依达拉奉注射液对豚鼠主动全身过敏反应未见明显过敏反应;未见明显体外溶血作用;对家兔耳缘静脉未见明显刺激作用。结论依达拉奉注射液的安全性试验结果提示其安全可靠。
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| 关 键 词： | 依达拉奉 安全性评价 自由基 |
Safety evaluation of edaravone injection |
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| Liu Lianggang,Song Jisheng,Shen Huaigui,Wu Biao. Safety evaluation of edaravone injection[J]. Anhui Medical Journal, 2011, 0(9): 1335-1337 |
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| Authors: | Liu Lianggang Song Jisheng Shen Huaigui Wu Biao |
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| Affiliation: | Liu Lianggang,Song Jisheng,Shen Huaigui,Wu Biao Outpatient Department of off Duty Cadres Rest House,Lu'an Military Subarea Anhui Province Military Area,Hefei 237000,Hefei Jiunuo Pharmaceutical and Technological Co.Ltd,Hefei 230088 |
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| Abstract: | Objective To evaluate the reliability of edaravone injection by testing the vessel stimulation,active systemic anaphylaxis,and haemolytic test.Methods The active systemic anaphylaxis was investigated by guinea pigs,reaction was observed when had injected edaravone injection on 21d after the first treatment.In the vessel stimulation,12 rabbits were observed for 7d after injecting edaravone injection,and the reaction after stopping treatment for 14d.In the haemolytic test,hemolysis and coagulation were mainly... |
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| Keywords: | Edaravone injection Safety evaluation Free redical |
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